Lung Disease,Obstructive Clinical Trial
| NCT number | NCT02592122 |
| Other study ID # | 2013-10-COPD |
| Secondary ID | |
| Status | Recruiting |
| Phase | N/A |
| First received | October 11, 2015 |
| Last updated | October 29, 2015 |
| Start date | October 2013 |
In the patients with COPD mechanical ventilation, the bronchial dilatation is very common. However, the evaluation of the efficacy of the medical examination and other subjective indicators, such as doctors, depends on the doctor's experience; at present, there is no objective evaluation index. For patients with mechanical ventilation, the risk of cross infection can not only increase the risk of cross infection, but also increase the workload of clinical doctors and nurses. Therefore, this study proposes an objective evaluation method to evaluate the response of COPD patients to bronchial dilation. The hypothesis of this study can be used to guide the clinical medication through the test of the bronchus. If the patients with bronchial dilation test positive were used in the test, the patients were not used. In this evaluation method, the changes of airway resistance were measured by the accurate measurement of the patients with inhaled bronchial dilatation.
| Status | Recruiting |
| Enrollment | 120 |
| Est. completion date | |
| Est. primary completion date | October 2016 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | N/A and older |
| Eligibility |
Inclusion Criteria: - Acute exacerbation of chronic obstructive pulmonary disease - The mechanical ventilation time of the outdoor endotracheal intubation in the intensive care unit was less than 48 hours Exclusion Criteria: - asthma - has received tracheotomy - long term mechanical ventilation (which has been accepted for more than 21 days). - severe pneumonia - Patients who cannot use a patient with bronchial dilation - there's a taboo on the use of a sedative. - refusal to participate in the study - 48 hours to pull out the tube |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
| Country | Name | City | State |
|---|---|---|---|
| China | Department of respiratory and critical care medicine,Beijing Chao-yang Hospital | Beijing | Beijing |
| Lead Sponsor | Collaborator |
|---|---|
| snow | Primary-investigator,Bing Sun |
China,
Li Y, Chen Y, Wang P. Application of impulse oscillometry and bronchial dilation test for analysis in patients with asthma and chronic obstructive pulmonary disease. Int J Clin Exp Med. 2015 Jan 15;8(1):1271-5. eCollection 2015. — View Citation
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | airway resistance | The first test of bronchial dilatation | 1 day | No |
| Primary | Respiratory mechanics index:PEEPi | 1 day | No | |
| Secondary | Mechanical ventilation time | 28 days | Yes | |
| Secondary | length of hospital stay | 30 days | Yes | |
| Secondary | Costs of hospitalization expenses | 30 days | No | |
| Secondary | Routine blood test:Eosinophilic cells | 7days | No |