Lung Cancer Clinical Trial
Official title:
Serum, Plasma, DNA and Tissue Bank of Patients With Chronic Obstructive Pulmonary Disease, Lung Cancer and Smoking Controls.
A biobank of Serum, plasma, DNA samples together with clinical information including
specific questionnaires, complete pulmonary function and chest CT-scan, is prospectively
collected in patients seen at the investigators' clinical service.
The objective is to study candidate gene pathways in COPD and or lung cancer and to
associate them with the clinical characteristics and phenotypes of COPD/emphysema and lung
cancer.
In subgroups of well characterised patients, other biological materials are also collected
(lung tissue biopsies, peripheral blood mononuclear cells).
All patients with a smoking history of at least 15 pack years, an minimal age of 50 years
and an recent available CT scan are enrolled.
All subjects with a diagnosis of lung cancer are also collected (irrespective of age and
smoking behavior).
In addition the investigators collect:
- specific questionnaires (MRC, CCQ and smoking history)
- medical and professional history
- complete pulmonary function (spirometry, bodyplethysmography and diffusing capacity)
- serum, plasma and DNA samples.
In specific subgroups the investigators also collect:
- Peripheral blood mononuclear cells
- Lung tissue - if available - from a surgical procedure (lung transplantation or
lobectomy)
;
Observational Model: Case Control, Time Perspective: Prospective
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