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Clinical Trial Summary

SLC-391 is a novel, potent and specific small molecule inhibitor of receptor tyrosine kinase AXL with desirable potency and pharmaceutical properties. The study is being done to evaluate the safety and pharmacokinetic (PK) profile of SLC-391 in combination with pembrolizumab in participants with non-small cell lung cancer (NSCLC). Each treatment cycle lasts 21 days. Participants will swallow SLC-391 pills two times every day. Participants will get pembrolizumab intravenously (IV) from the study site staff on the first day of every cycle. This study has 2 parts. The first part will determine the recommended dose of SLC-391 in combination with pembrolizumab. The second part wants to find out if the combination of SLC-391 and pembrolizumab can help stop NSCLC tumours from growing or spreading.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05860296
Study type Interventional
Source SignalChem Lifesciences Corporation
Contact Zaihui Zhang, PhD
Phone 1-604-232-4600
Email zzhang@signalchemcorp.com
Status Recruiting
Phase Phase 1/Phase 2
Start date May 31, 2023
Completion date December 2027

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