Plasmodium Immunotherapy for Lung Cancer

Status Recruiting

Clinical Trial Summary

The objective of this study is to evaluate the safety and the effectiveness of Plasmodium immunotherapy (blood-stage infection of Plasmodium vivax) for advanced non-small cell lung cancer.The treatment will last 3-6 months from the day of successful infection and will be terminated by antimalarial drugs.

Clinical Trial Description

In our study，30 patients with stage III/IV NSCLC will be enrolled to receive vaccination with an optimal concentration and amount of blood-stage P. vivax to observe the infection time, rate and cycle; principal clinical symptoms such as fever and anemia; heart, liver and kidney function; changes in spleen morphology and function, and dynamic changes in the function of peripheral immune cells. Moreover, the patient's tolerance to Plasmodium infection and changes in tumor-related parameters will be observed. The duration of the planned treatment is 3-6 months, and successful infection will be indicated by microscopic observation of parasitemia in peripheral blood samples. The treatment will last at least 12 weeks from the day of finding the Plasmodium from peripheral blood and will be terminated by chloroquine phosphate or Artemisinin compound preparation or Artesunate injection. Each patient will be vaccinated with P. vivax-infected red blood cells containing approximately 0.3-1×10^7 Plasmodium parasites. After vaccination, the onset and duration of peripheral parasitemia and the infection rate; principal clinical symptoms such as Chills, fever, pain (headache, joint pain, etc.), digestive tract reaction;peripheral hemogram changes；heart, liver and kidney function; changes in lung function, and dynamic changes in the function of peripheral immune cells will be observed. Moreover, the patient's tolerance to Plasmodium infection and changes in tumor-related parameters will be observed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02786589
Study type	Interventional
Source	State Key Laboratory of Respiratory Disease
Contact	Chengzhi Zhou, M.D.
Phone	0086-20-83062888
Status	Recruiting
Phase	Phase 1/Phase 2
Start date	June 27, 2016
Completion date	December 30, 2023

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT06003075` - Induction Chemo-Nivo in Unresectable Stage III NSCLC	Phase 2
Enrolling by invitation	`NCT06293833` - Implementation of Lung Cancer Screening in the First Line Zone of ZORA (Flanders), Using a Low Dose CT-scan	N/A
Recruiting	`NCT03705806` - Palliative Thoracic ImmunoRT
Not yet recruiting	`NCT06060964` - Enabling Remote Access to Breathe Easier: A Novel Approach to Improve Symptom Management	Early Phase 1
Completed	`NCT04634630` - The Influence of Cancer Stem-cells on Risk of Relapse in Patients Harboring Adenocarcinoma and Squamous Cell Carcinoma of the Lung
Completed	`NCT03689634` - Move For Surgery - A Novel Preconditioning Program	Phase 3
Recruiting	`NCT05537922` - I3LUNG: Integrative Science, Intelligent Data Platform for Individualized LUNG Cancer Care With Immunotherapy
Completed	`NCT03902834` - Move for Surgery (MFS): Evaluating the Use of Wearable Technology for Preconditioning Before Thoracic Surgery	N/A
Active, not recruiting	`NCT03322072` - Calypso Guided High Precision Stereotactic Ablative Radiosurgery for Lung TUmours Using Real-Time Tumour Tracking & Respiratory Gating	N/A
Completed	`NCT02995889` - FLT-PET for Early Detection of Relapse in Patients With Irradiated Lung Cancer	N/A
Recruiting	`NCT04237805` - A Phase I/II Clinical Study of SAF-189s in Non-small Cell Lung Cancer (NSCLC) Patients	Phase 1/Phase 2
Terminated	`NCT05061940` - This SCR-103 Protocol Will Permit Sites to Proactively Assess TAA, HLA and HPV-16 Status in Patients With Selected Solid Tumors to Determine Suitability for Repertoire Immune Medicines Treatment Protocols.
Recruiting	`NCT05860296` - Testing Experimental Anti-cancer Drug SLC-391 With an Approved Immunotherapy Drug, Pembrolizumab, for Advanced Lung Cancers	Phase 1/Phase 2
Enrolling by invitation	`NCT05863013` - Use of the ADL-Glittre Test in the Pre and Postoperative Period of Patients With Lung Cancer	N/A
Suspended	`NCT02991651` - Study of IRX4204 With Erlotinib in Previously Treated Advanced NSCLC	Phase 1
Enrolling by invitation	`NCT04678440` - [18F]F-AraG/Total Body PET Imaging and Healthy Subjects and Lung Cancer Patients	Early Phase 1
Recruiting	`NCT04222335` - Understanding and Overcoming the Early Adaptive Resistance to EGFR Tyrosine-kinase Inhibitors in Lung Cancer Patients	N/A
Recruiting	`NCT04415320` - X-396 (Ensartinib) Capsules in ALK-Positive NSCLC Patients With Brain Metastases	Phase 2
Recruiting	`NCT05085028` - A Randomised Open-label Phase III Trial of REduced Frequency Pembrolizumab immuNothErapy for First-line Treatment of Patients With Advanced Non-small Cell Lung Cancer (NSCLC)	Phase 3
Recruiting	`NCT05956782` - Breathe Easier II: A Dyad-based Multiple Behavior Intervention	N/A