Low-grade Inflammation Clinical Trial
Official title:
Effect of Milk Ingredients on Glucose Regulation and Inflammation in Overweight Subjects
Background: Recent advances in science have established a fundamental role for low grade
chronic inflammation in mediating all stages of most of the non-communicable diseases
associated with ageing. Pro-inflammatory effects of hyperglycemia have been described. Dairy
and its components are known to exert beneficial effects on postprandial hyperglycemia. This
study investigates if dairy, normal and enriched, can reduce chronic inflammation via
improvement in glucose regulation.
Objective: To compare the effect of a nutrient-enriched dairy drink on parameters of glucose
regulation and postprandial inflammation with the effect of a standard milk drink, within a
population of overweight, apparently healthy subjects.
Study design: The study is designed as a double-blind randomized placebo-controlled parallel
trial during 7 weeks, during which the test and reference products will be consumed at home.
Main study parameters/endpoints: The difference in absolute change in fasting blood plasma
concentration of glucose, insulin and IL-6, from baseline to endpoint, and the difference in
postprandial response of plasma concentration of glucose, insulin and IL-6 at the end of the
treatment period, between subjects consuming the test and reference product.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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