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NCT06307158 Clinical Trial

Influence of Intraoperative Blood Salvage and Autotransfusion on Tumor Recurrence After Deceased Donor Liver Transplantation

Liver Transplant; Complications Clinical Trial

Official title:
Influence of Intraoperative Blood Salvage and Autotransfusion on Tumor Recurrence After Deceased Donor Liver Transplantation

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT06307158
Other study ID # CT2024-ZJU-OBS1
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2015
Est. completion date December 31, 2021

Study information
Verified date March 2024
Source Zhejiang University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The practice of intraoperative blood salvage and autotransfusion (IBSA) during deceased donor liver transplantation (DDLT) for hepatocellular carcinoma (HCC) can potentially reduce the need for allogeneic blood transfusion. However, implementing IBSA remains debatable due to concerns about its possible detrimental effects on oncologic recurrence. Hence, a nationwide multi-center study was conducted to investigate further the association between IBSA and post-transplant HCC recurrence, including a stratified subgroup analysis.

Recruitment information / eligibility
Status Completed
Enrollment 998
Est. completion date December 31, 2021
Est. primary completion date December 31, 2020
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - adult-to-adult deceased donor liver transplantation for hepatocellular carcinoma Exclusion Criteria: - patients under 18 years of age - presence of extrahepatic metastasis - combined kidney transplantation - reduced-size or split liver transplantation - re-transplantation

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (2)
Lead Sponsor Collaborator
Zhejiang University Shulan (Hangzhou) Hospital

Outcome
Type Measure Description Time frame Safety issue
Primary Postoperative recurrence of liver cancer The overall incidence of HCC recurrence (intrahepatic or extrahepatic) after LT. 2015.1.1-2020.12.31
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