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Liver Metastases clinical trials

View clinical trials related to Liver Metastases.

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NCT ID: NCT06404593 Completed - Colorectal Cancer Clinical Trials

Dynamic ctDNA Detection for Colorectal Cancer Liver Metastases

Start date: June 18, 2019
Phase:
Study type: Observational

Evaluating the value of dynamic monitoring of a colorectal cancer liver metastasis cohort underwent curative resection after receiving multipoint ctDNA detecting in predicting recurrence prognosis and guiding adjuvant chemotherapy treatment.

NCT ID: NCT06184841 Completed - Clinical trials for Esophageal Squamous Cell Carcinoma

HAIC Combined Sintilimab for Liver Metastasis From Esophageal Squamous Cell Carcinoma

Start date: June 18, 2020
Phase: Phase 1
Study type: Interventional

Patients with liver metastasis from esophagus squamous (ESC) are usually offered systemic therapy. However, for those with predominant liver disease or failure of system therapy, local liver management becomes an option. This prospective single center study aimed to evaluate the efficacy and adverse events of hepatic arterial infusion chemotherapy (HAIC) using percutaneous catheter placement techniques for liver metastases from esophagus squamous (ESC).

NCT ID: NCT06038552 Completed - Liver Metastases Clinical Trials

The Long-term Efficacy of Imatinib With Hepatic Resection or Other Local Treatment for GIST Liver Metastases

Start date: January 1, 2002
Phase:
Study type: Observational

The goal of this observational study is to evaluate the overall survival benefits of local treatment combined with imatinib(IM) and IM alone in patients suffering from GIST liver metastases. The main question it aims to answer is: • Whether IM combined with hepatic resection (HR) or other local treatments such as radiofrequency ablation (RFA) and transarterial chemoembolization (TACE) has better long-term survival benefits compared to IM monotherapy. Patients are divided into different treatment groups: - IM group - IM combined with HR group - IM combined with RFA or TACE group Researchers will compare the IM + HR group and IM + RFA/TACE group with the IM group to see if it has a better Overall survival (OS).

NCT ID: NCT05779865 Completed - Liver Metastases Clinical Trials

Study of Different Gating Techniques for PET Image of Lung and Liver Lesions

PETGATQUANT
Start date: February 15, 2023
Phase:
Study type: Observational

Lesions blurred by respiratory motion are common in fluorine-18 PET/CT studies. To avoid these artefacts, several standard gating correction technics are available. the investigator aimed to compare the impact of different gating techniques based on phase, amplitude, elastic-motion monitored with and without pressurre sensor device on standardized uptake value (SUVmax and SUVpeak) and uptake volume (UV) measurements on different sizes of pulmonary and liver lesions. The feasability of this study will be done using anthropomorphic coupled with a motion phantom and on a series of patients.

NCT ID: NCT05475054 Completed - Obesity Clinical Trials

Impact of Minimally Invasive and Open Liver Surgery in Different BMI-classes

MILSOBES
Start date: December 1, 2020
Phase:
Study type: Observational

Despite the worldwide increase of both obesity and use of minimally invasive liver surgery(MILS), evidence regarding the safety and eventual benefits of MILS in obese patients is scarce. The aim of this study is therefore to compare the outcomes of non-obese and obese patients(BMI 18.5-29.9 and BMI≥30, respectively) undergoing MILS and OLS, and to assess trends in MILS use among obese patients. In this retrospective cohort study, patients operated at 20 hospitals in eight countries(2009-2019) will be included and the characteristics and outcomes of non-obese and obese patients will be compared. Thereafter, the outcomes of MILS and OLS were compared in both groups after propensity-score matching(PSM). Changes in the adoption of MILS during the study period will be investigated.

NCT ID: NCT05462470 Completed - Colorectal Cancer Clinical Trials

Impact of Surgical Management for Relapse After Conversion Hepatectomy for Initially Unresectable Colorectal Liver Metastasis

Start date: January 1, 2008
Phase:
Study type: Observational

For patients with initially unresectable colorectal liver metastasis (IU-CRLM) receiving effective conversion therapy, disease relapse after conversion hepatectomy is common due to the extensive tumor load. Yet, few studies have focused on the assessment and management of relapse after conversion hepatectomy for IU-CRLM. This study aimed to investigate the impact of surgical management for relapse after conversion hepatectomy in IU-CRLM.

NCT ID: NCT05273489 Completed - Liver Metastases Clinical Trials

Chemotherapy and Tumor Clearance in Hepatic Resections for Colorectal Liver Metastases.

Start date: January 1, 2004
Phase:
Study type: Observational [Patient Registry]

Retrospective analysis of a prospectively collected database of 170 patients between 2004 and 2020, who underwent liver resections for CRLM (colorectal liver metastases) at The Queen Elizabeth Hospital trying to determine rates and patterns of recurrence following liver resections for CRLM and concurrently, characterise clinical, pathological and treatment-related factors that could function as predictors of recurrence or survival, particularly neoadjuvant chemotherapy and tumour clearance.

NCT ID: NCT05036265 Completed - Colorectal Cancer Clinical Trials

Prognostic Factors and Oncological Outcomes in Laparoscopic Liver Resection for CRLM

Start date: September 1, 2011
Phase:
Study type: Observational

Laparoscopic liver resection (LLR) has gained acceptance as an effective treatment for colorectal liver metastases (CRLM) in selected patients, providing similar oncologic outcomes compared to open liver resection (OLR). A single-center retrospective analysis of a prospectively maintained database was performed. The primary aim of this study was to determine prognostic factors for the survival outcomes associated with LLR for CRLM.

NCT ID: NCT04942665 Completed - Clinical trials for Hepatocellular Carcinoma

Low Dose ICG for Biliary Tract and Tumor Imaging

ICG
Start date: September 15, 2021
Phase: Phase 2
Study type: Interventional

Near-infrared fluorescence (NIRF) imaging after an intravenous injection of indocyanine green (ICG) allows for the intraoperative identification of liver anatomy. The investigators have new data that a much lower dose improves this visualization. Confirmation of this hypothesis would mean that ICG can be administered on the same day of surgery in order to augment real-time intraoperative visualization, thereby providing a safe, feasible, and cost-effective strategy for the surgical treatment of liver disease.

NCT ID: NCT04880772 Completed - Liver Metastases Clinical Trials

Clinical Trial Comparing Standard Care Versus Prehabilitation in Patients Undergoing Cancer Surgery

SPECS
Start date: July 15, 2021
Phase: N/A
Study type: Interventional

To determine whether exercise and nutrition prehabilitation improves patient outcomes after cancer surgery