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Liver Cirrhosis clinical trials

View clinical trials related to Liver Cirrhosis.

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NCT ID: NCT02319200 Terminated - Clinical trials for Hepatocellular Carcinoma

Primary Prevention Hepatocellular Carcinoma by Metformin

METFOVIR
Start date: June 2015
Phase: Phase 3
Study type: Interventional

Metformin treatment during 36 months could be associated with decreased risk of HCC occurrence and liver related death in patients with compensated HCV cirrhosis and insulinoresistance. This study is an ancillary of the observational study from the CIRVIR cohort in which more than 1200 patients with compensated HCV cirrhosis are currently included. participating centers : 26

NCT ID: NCT02313896 Terminated - Cirrhosis Clinical Trials

Cirrhosis Readmission Telehealth Project

Start date: July 2014
Phase: N/A
Study type: Interventional

This is a 2 year research study to study if post discharge phone calls can help lengthen time to hospital readmissions for patients with encephalopathy.

NCT ID: NCT02313649 Completed - Liver Fibrosis Clinical Trials

ShearWave™ Elastography to Assess Liver Fibrosis in Chinese Patients With Hepatitis B

Start date: December 2014
Phase: N/A
Study type: Observational

This study will evaluate how liver stiffness measurements made with ShearWave™ Elastography (SWE) correspond with a biopsy result (currently the gold standard). The population that will be evaluated are Chinese patients infected with the Hepatitis B virus.

NCT ID: NCT02311985 Terminated - Liver Cirrhosis Clinical Trials

Comparison of Three Transfusion Strategies for Central Venous Catheterization in Cirrhotics: A Randomized Clinical Trial

POCKET
Start date: September 2014
Phase: N/A
Study type: Interventional

The aim of this study is to compare three different blood transfusion strategies for coagulopathy correction before central venous catheterization in patients with chronic liver failure (cirrhosis and/or chronic liver graft dysfunction) admitted in intensive care unit.

NCT ID: NCT02311608 Recruiting - Liver Cirrhosis Clinical Trials

Effects of Terlipressin When Usual Somatostatin or Octreotide Dose Fails

CER:T
Start date: February 2014
Phase: N/A
Study type: Observational

To observe and access the Effects and safety of terlipressin or high dose somatostatin/octreotide when usual dose somatostatin/octreotide fail to achieve hemostasis in patients with acute variceal bleeding.

NCT ID: NCT02308111 Terminated - Clinical trials for Liver Cirrhosis, Biliary

Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis

COBALT
Start date: December 26, 2014
Phase: Phase 4
Study type: Interventional

Primary Biliary Cholangitis (PBC) is a serious, life-threatening, bile acid related liver disease of unknown cause. Without treatment, it frequently progresses to liver fibrosis and eventual cirrhosis requiring liver transplantation or resulting in death. The investigational drug, Obeticholic Acid (OCA) is a modified bile acid and FXR agonist that is derived from the primary human bile acid chenodeoxycholic acid. The key mechanisms of action of OCA, including its choleretic, anti-inflammatory, and anti-fibrotic properties, underlie its hepatoprotective effects and result in attenuation of injury and improved liver function in a cholestatic liver disease such as PBC. The study will assess the effect of OCA compared to placebo, combined with stable standard care, on clinical outcomes in PBC participants.

NCT ID: NCT02298868 Completed - Cirrhosis Clinical Trials

Safety and Efficacy of Baclofen for Treatment of Muscle Spasms in Patients With Cirrhosis: A Pilot Study

Start date: October 2012
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the safety and efficacy of the medication Baclofen for treatment of muscle cramps in patients with cirrhosis.

NCT ID: NCT02297867 Completed - Liver Cirrhosis Clinical Trials

Clinical Trial Study About Human Adipose-Derived Stem Cells in the Liver Cirrhosis

Start date: July 13, 2015
Phase: Phase 1
Study type: Interventional

The aim of the investigators study was to investigate the safety and efficacy of autologous ADSCs for the clinical treatment of liver cirrhosis.

NCT ID: NCT02292706 Terminated - Clinical trials for Hepatitis C Virus Infection

A Registry for Participants With Cirrhosis Who Achieve a Sustained Virologic Response Following Treatment With a Sofosbuvir-Based Regimen Without Interferon for Chronic Hepatitis C Infection

Start date: December 29, 2014
Phase:
Study type: Observational [Patient Registry]

The primary objective of this registry study is to assess the durability of sustained virologic response (SVR) and clinical progression or regression of liver disease including the incidence of hepatocellular carcinoma following SVR in participants with cirrhosis after treatment with a sofosbuvir-based regimen for HCV infection.

NCT ID: NCT02289300 Withdrawn - Clinical trials for Hepatocellular Carcinoma

A Study to Evaluate a Study Drug, DCB-BO1202, for Alleviating Liver Fibrosis in Liver Cancer Patients

Start date: January 2020
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether an investigational drug DCB-BO1202 is effective and safe in the treatment of liver fibrosis in HBV patients having experienced intermediate stage hepatocellular carcinoma (HCC)