Limbal Stem Cell Deficiency Clinical Trial
Official title:
Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency Disease
The aim of this trials investigates the therapeutic effects of application autologous oral mucosal epithelial cell sheets in the treatment of limbal stem cell deficiency disease.
A number of external factors can result in limbal stem cell deficiency(LSCD), causing pain, pathological corneal epithelium regeneration, inflammation reaction and seriously visual loss. For patients with unilaterally damaged eye, transplantation of limbal tissue from the healthy eye can be used in the past years in the risk of inducing limbal stem cell damaged in the healthy eye. While graft of human leukocyte antigen matched allogenic limbal stem cells require immune suppressive medications, it can cause side effects in the body. Over the past 10 years, the clinical trials of application of cultured autologous oral mucosal epithelial cell sheet to treat LSCD have been emerged as a promising strategy in many countries. However, little study has been reported in China. This study investigates the therapeutic effects of application autologous oral mucosal epithelial cell sheets in the treatment of limbal stem cell deficiency disease in China. ;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02568527 -
Biodegradable Synthetic Scaffold as a Substitute for hAM in Limbal Epithelial Cells Transplant in LSCD Patients
|
N/A | |
| Completed |
NCT00736307 -
Autologous Transplantation of Cultivated Limbal Stem Cells on Amniotic Membrane in Limbal Stem Cell Deficiency (LSD) Patients
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT06412718 -
Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies
|
||
| Available |
NCT02149732 -
Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation
|
Phase 1/Phase 2 | |
| Recruiting |
NCT06452316 -
Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Limbal Stem Cell Deficiency
|
Phase 1 | |
| Terminated |
NCT02579993 -
ABCB5 as a Prognostic Marker in Survival of Cultivated Limbal Stem Cell Transplantation
|
N/A | |
| Recruiting |
NCT03943797 -
Cultivated Autologous Oral Mucosal Epithelial Transplantation
|
Phase 1 | |
| Active, not recruiting |
NCT03549299 -
Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of LSCD
|
Phase 1/Phase 2 | |
| Completed |
NCT03217435 -
Corneal Epithelial Allograft From Living-related Donor for LSCD
|
N/A | |
| Recruiting |
NCT03217487 -
Corneal Epithelial Autograft for LSCD
|
N/A | |
| Active, not recruiting |
NCT00845117 -
Cultivated Stem Cell Transplantation for the Treatment of Limbal Stem Cell Deficiency
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT02739113 -
Cultivated Autologous Oral Mucosal Epithelial Transplantation for the Treatment of Ocular Surface Diseases
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT06265298 -
Implementation of a Protocol for the Transdifferentiation of Buccal Mucosal Epithelium Into Corneal Epithelium
|
N/A | |
| Recruiting |
NCT01756365 -
Autologous Cultured Corneal Epithelium (CECA) for the Treatment of Limbal Stem Cell Deficiency
|
N/A | |
| Completed |
NCT02592330 -
Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft
|
Phase 1/Phase 2 | |
| Recruiting |
NCT02318485 -
Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter Trial
|
Phase 2 | |
| Withdrawn |
NCT01489501 -
Multicenter Study of CAOMECS Transplantation to Patients With Total Limbal Stem Cell Deficiency
|
Phase 3 |