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Clinical Trial Summary

In this study the prognostic value of ABCB5 in survival of the limbal stem cell transplantation expanded in vitro on amniotic membrane for corneal surface reconstruction in patients with limbal stem cell deficiency will be analyzed.


Clinical Trial Description

There are several diseases that cause the cornea to lose its clarity and directly affects the vision of the individual, therefore, the use of limbal stem cells has been having increasing acceptance in the field of medical therapy. An open clinical study is running with patients with limbal stem cell deficiency, performing a limbal stem cell transplantation expanded in vitro on amniotic membrane and the value of ABCB5 as a prognostic factor in the survival of transplant will be determined. The corneal surface status will be the primary endpoint. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02579993
Study type Interventional
Source Instituto de Oftalmología Fundación Conde de Valenciana
Contact
Status Terminated
Phase N/A
Start date March 2015
Completion date March 2018

See also
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Completed NCT00736307 - Autologous Transplantation of Cultivated Limbal Stem Cells on Amniotic Membrane in Limbal Stem Cell Deficiency (LSD) Patients Phase 1/Phase 2
Available NCT02149732 - Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation Phase 1/Phase 2
Recruiting NCT03943797 - Cultivated Autologous Oral Mucosal Epithelial Transplantation Phase 1
Active, not recruiting NCT03549299 - Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of LSCD Phase 1/Phase 2
Completed NCT03217435 - Corneal Epithelial Allograft From Living-related Donor for LSCD N/A
Recruiting NCT03217487 - Corneal Epithelial Autograft for LSCD N/A
Active, not recruiting NCT00845117 - Cultivated Stem Cell Transplantation for the Treatment of Limbal Stem Cell Deficiency Phase 1/Phase 2
Enrolling by invitation NCT03015779 - Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency Disease Phase 1/Phase 2
Active, not recruiting NCT02739113 - Cultivated Autologous Oral Mucosal Epithelial Transplantation for the Treatment of Ocular Surface Diseases Phase 1/Phase 2
Not yet recruiting NCT06265298 - Implementation of a Protocol for the Transdifferentiation of Buccal Mucosal Epithelium Into Corneal Epithelium N/A
Recruiting NCT01756365 - Autologous Cultured Corneal Epithelium (CECA) for the Treatment of Limbal Stem Cell Deficiency N/A
Completed NCT02592330 - Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft Phase 1/Phase 2
Recruiting NCT02318485 - Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter Trial Phase 2
Withdrawn NCT01489501 - Multicenter Study of CAOMECS Transplantation to Patients With Total Limbal Stem Cell Deficiency Phase 3