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Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency Disease

Limbal Stem Cell Deficiency Clinical Trial

Official title:
Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency Disease

Clinical Trial Summary

The aim of this trials investigates the therapeutic effects of application autologous oral mucosal epithelial cell sheets in the treatment of limbal stem cell deficiency disease.

Clinical Trial Description

A number of external factors can result in limbal stem cell deficiency(LSCD), causing pain, pathological corneal epithelium regeneration, inflammation reaction and seriously visual loss. For patients with unilaterally damaged eye, transplantation of limbal tissue from the healthy eye can be used in the past years in the risk of inducing limbal stem cell damaged in the healthy eye. While graft of human leukocyte antigen matched allogenic limbal stem cells require immune suppressive medications, it can cause side effects in the body. Over the past 10 years, the clinical trials of application of cultured autologous oral mucosal epithelial cell sheet to treat LSCD have been emerged as a promising strategy in many countries. However, little study has been reported in China. This study investigates the therapeutic effects of application autologous oral mucosal epithelial cell sheets in the treatment of limbal stem cell deficiency disease in China. ;

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03015779
Study type Interventional
Source He Eye Hospital
Contact
Status Enrolling by invitation
Phase Phase 1/Phase 2
Start date January 2017
Completion date December 2018
View Details
See also
  Status Clinical Trial Phase
Completed NCT02568527 - Biodegradable Synthetic Scaffold as a Substitute for hAM in Limbal Epithelial Cells Transplant in LSCD Patients N/A
Completed NCT00736307 - Autologous Transplantation of Cultivated Limbal Stem Cells on Amniotic Membrane in Limbal Stem Cell Deficiency (LSD) Patients Phase 1/Phase 2
Available NCT02149732 - Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation Phase 1/Phase 2
Terminated NCT02579993 - ABCB5 as a Prognostic Marker in Survival of Cultivated Limbal Stem Cell Transplantation N/A
Recruiting NCT03943797 - Cultivated Autologous Oral Mucosal Epithelial Transplantation Phase 1
Active, not recruiting NCT03549299 - Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of LSCD Phase 1/Phase 2
Completed NCT03217435 - Corneal Epithelial Allograft From Living-related Donor for LSCD N/A
Recruiting NCT03217487 - Corneal Epithelial Autograft for LSCD N/A
Active, not recruiting NCT00845117 - Cultivated Stem Cell Transplantation for the Treatment of Limbal Stem Cell Deficiency Phase 1/Phase 2
Active, not recruiting NCT02739113 - Cultivated Autologous Oral Mucosal Epithelial Transplantation for the Treatment of Ocular Surface Diseases Phase 1/Phase 2
Not yet recruiting NCT06265298 - Implementation of a Protocol for the Transdifferentiation of Buccal Mucosal Epithelium Into Corneal Epithelium N/A
Recruiting NCT01756365 - Autologous Cultured Corneal Epithelium (CECA) for the Treatment of Limbal Stem Cell Deficiency N/A
Completed NCT02592330 - Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft Phase 1/Phase 2
Recruiting NCT02318485 - Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter Trial Phase 2
Withdrawn NCT01489501 - Multicenter Study of CAOMECS Transplantation to Patients With Total Limbal Stem Cell Deficiency Phase 3