Leukemia, Lymphocytic, Acute, L1 Clinical Trial
Official title:
Incidence of Osteoporosis in Children With Acute Lymphoblastic Leukemia Undergoing Therapy
Hypothesis:
Pediatric patients with acute lymphoblastic leukemia, treated with chronic glucocorticoids
as a part of the leukemia treatment protocol, will have an increased incidence and severity
of osteoporosis.
Osteoporosis is a disease characterized by low bone mass and microarchitectural
deterioration of bone tissue. Osteoporosis is a devastating disorder with significant
physical, psychosocial and financial consequences. Intensive chemotherapy and radiotherapy
have led to significant improvements in long term, disease-free survival of children with
malignancies. Unfortunately, there are many deleterious side effects associated with this
therapy. Little is known about the longitudinal changes in bone mass accumulation and bone
metabolism in these patients.
The purpose of this study is to evaluate the timing and severity of changes in bone mineral
metabolism for children treated for childhood leukemia. Data will be used to establish
treatment protocols with the goal of preventing severe fractures and pain in the acute
treatment stage and severe osteoporosis and related pathology in the chronic stage.
;
Observational Model: Defined Population, Time Perspective: Longitudinal
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT01100658 -
Effects of Methylphenidate on Attention Deficits in Childhood Cancer Survivors
|
N/A |