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Maternal Epidural Steroids and Hyperthemia

Labor Pain Clinical Trial

Official title:
Maternal Epidural Steroids to Prevent Neonatal Exposure to Hyperthermia and Inflammation

Clinical Trial Summary

The purpose of this study is to look to see if adding steroids to an epidural reduces the chances of having a fever in labor, and protects the baby from exposure to inflammation.

Clinical Trial Description

The association between epidural analgesia and increased maternal intrapartum temperature has been well documented in multiple randomized controlled trials. The exact mechanism for this elevation in temperature is unknown; however the most likely cause appears to be non-infectious inflammatory stimulation. Fetal exposure to maternal fever in utero has been linked with increased antibiotic treatment, increased neonatal sepsis evaluation, and longer length of stay for neonates. In addition there is evidence to suggest intrapartum fevers may lower the threshold for fetal hypoxic brain injury and increase the risk of cerebral palsy. The risk of neonatal encephalopathy in infants born to febrile mothers is 1% compared to 0.1% to afebrile mothers. Safe interventions are needed to prevent adverse fetal outcomes. ;

Study Design

Related Conditions & MeSH terms

  • Complication of Anesthesia During Pregnancy, Unspecified
  • Fever
  • Labor Pain
Clinical Trial Details
NCT number NCT02212210
Study type Interventional
Source Medical University of South Carolina
Contact
Status Terminated
Phase Early Phase 1
Start date February 2012
Completion date October 2015
View Details
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