Maximal Rate of Force Development of Ankle Muscles and Functional Ability in Patients With Knee Osteoarthritis

Knee Osteoarthritis Clinical Trial

Official title:

Assessment of Maximal Rate of Force Development of Ankle Muscles and Its Association Functional Ability in Patients With Knee Osteoarthritis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06063889
• Other study ID #: 012/90002023
• Status: Recruiting
• Start date: July 20, 2023
• Est. completion date: October 2, 2023

Study information

• Verified date: September 2023
• Source: Ahram Canadian University
• Contact: Mohamed ElMeligie, Ph.D
• Phone: +201064442032
• Email: mohamed.elmeligie[@]acu.edu.eg
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study is a detailed assessment of the maximal rate of force development of ankle muscles and its association with functional ability in patients with knee osteoarthritis (OA).

Description:

This research is designed to study the link between force development in ankle muscles and functional abilities in knee OA patients. It aims to understand the influence of ankle muscle strength, specifically plantar flexors, on the stability, pain, and functionality of patients with knee OA. The study will analyze the rate of force development, its importance in explosive strength improvement, and impact on preventing knee injuries. Furthermore, it will investigate the compensatory mechanism of the plantar flexors developed by patients in advanced stages to balance other muscle failures.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 126
• Est. completion date: October 2, 2023
• Est. primary completion date: October 2, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 30 Years to 45 Years

Eligibility

Inclusion Criteria:

• Group 1 (Knee OA group)

1. Patients diagnosed with knee osteoarthritis according to Performance of the 2018 classification criteria for early stage knee OA was tested using data from the Osteoarthritis Initiative (OAI (Leung et al.,2020).

2. Grade 2-3 KOA cases according to Kelgren-Lawrance classification

3. Having knee pain for at least 6 months.

4. The visual analog scale (VAS) score being at least 3 or more.

• Group 2 (Healthy control group) 1. Individuals with no signs or symptoms of Knee OA or other neurological or musculoskeletal conditions.

Exclusion Criteria:

1. Patellar subluxation

2. Surgery in any joint of the lower limb

3. Meniscal injury

4. Ligament instability

5. Patients who received intra-articular injection in the knee in the last 6 months

6. Patients with problems in the hip and ankle

7. Patients who participated in in another physical therapy program in the last 3 months were not included in the study.

Related Conditions & MeSH terms

• Knee Arthritis
• Knee Osteoarthritis
• Osteoarthritis
• Osteoarthritis, Knee

Intervention

Diagnostic Test:
• Maximal Rate of Force Development Test for Ankle Muscles
This test is designed to measure the maximal rate of force development in the ankle muscles, specifically the plantar flexors. It aims to assess the relationship between the strength of these muscles and the functional ability in patients with knee osteoarthritis. The results from this test will help to understand how lower limb muscle strength influences the symptoms and progression of knee osteoarthritis.

Locations

Country	Name	City	State
Egypt	Outpatient clinic of faculty of physical therapy, Ahram Canadian University	Al ?ayy Ath Thamin	Giza

Sponsors (1)

Lead Sponsor	Collaborator
Ahram Canadian University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Knee Osteoarthritis Outcome Score (KOOS)	The KOOS is a questionnaire that assesses five aspects of knee injury and osteoarthritis: pain, symptoms, ADL function, sport and recreation function, and quality of life. Scores are transformed to a 0-100 scale, with zero representing extreme knee problems and 100 representing no knee problems. Higher scores indicate better function and less pain.	Baseline
Primary	Forward Step Down Test (FSDT)	This functional ability test requires participants to perform as many repetitions as possible in 30 seconds of a specific movement. The number of valid repetitions performed in this duration is recorded.	Baseline
Primary	Single Leg Hop Test (SLHT)	n this test, participants hop forward as far as possible on one leg, and the distance hopped is recorded.	Baseline
Primary	Isokinetic Testing Procedures	This procedure involves conducting tests of three (60°/s) or five (120°/s) maximal nonconsecutive efforts with specific rest intervals. Each subject is instructed to exert maximal effort throughout the whole range of motion.	Baseline
Primary	Rate of Force Development (RFD)	The RFD is a measure of the speed at which the force of a muscle contraction develops. It is typically measured during isometric contractions and provides information about the muscle's explosive strength capacity.	Baseline