Metformin as Adjuvant Therapy in Obese Knee Osteoarthritis Patients

Status Completed

Clinical Trial Summary

This study aims to evaluate the possible efficacy and safety of addition of metformin to celecoxib in patients with knee osteoarthritis.

Clinical Trial Description

Metformin is a safe, well-tolerated oral biguanide widely used as first-line therapy for type 2 diabetes for over 50 years. In addition to its glucose-lowering effects, metformin modulates inflammatory and metabolic factors resulting in weight loss and reduced inflammation and plasma lipids. Data from animal studies suggest that metformin could limit OA development and progression, possibly through activating AMPK. Retrospective cohort study of participants with OA and type 2 diabetes reported that patients receiving a combination of cyclooxygenase-2 inhibitors and metformin therapy had a lower risk of joint replacement than those receiving cyclooxygenase-2 inhibitors alone . These findings shed light on possible therapeutic potential of metformin in treatment of OA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05638893
Study type	Interventional
Source	Tanta University
Contact
Status	Completed
Phase	Phase 2/Phase 3
Start date	February 1, 2021
Completion date	April 15, 2022

View Details

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