Femoral Cartilage Thickness in Knee Osteoarthritis

Knee Osteoarthritis Clinical Trial

Official title:

Investigation of the Relationship Between Femoral Cartilage Thickness and Inflammatory Parameters, Pain Severity and Functionality in Knee Osteoarthiritis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05456711
• Other study ID #: KAEK/2022.05.103
• Status: Recruiting
• Start date: May 15, 2022
• Est. completion date: July 15, 2022

Study information

• Verified date: July 2022
• Source: Kanuni Sultan Suleyman Training and Research Hospital
• Contact: Merve D. Korkmaz, M.D.
• Phone: +905556297264
• Email: mervedml[@]gmail.com
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The aim of the study to investigate the relationship between femoral cartilage thickness in Ultrasonographic evaluation and inflammatory parameters, pain severity and functionality in participants with Knee Osteoarthritis

Description:

Aim: The aim of the study is to investigate the relationship between femoral cartilage thickness and inflammatory parameters, pain severity and functionality in participants with Knee Osteoarthritis.

Methods: This study is designed as a prospective, cross-sectional trial. 90 participants aged between 50-65 years with knee osteoarthritis(OA) and at least 50 participants without any symptom for knee OA are included in the study in accordance with the inclusion criteria. Participants' demographic characteristics will be evaluated, and ultrasonographic measurement will be performed for measuring femoral cartilage thickness. Visual Analog scale will be used for pain severity and Western Ontario and McMaster Universities Osteoartrit index (WOMAC) will be used for assessing functionality of the patients. Also hematologic parameters(neutrophils, leucocytes, lymphocytes, platelet, CRP, erythrocyte sedimentation rate) will be evaluated for investigating the inflammation. The relationship between femoral cartilage thickness and inflammatory parameters, pain severity and functionality in knee osteoarthritis will be analysed for both group.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 140
• Est. completion date: July 15, 2022
• Est. primary completion date: July 15, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 50 Years to 65 Years

Eligibility

Inclusion Criteria:

• diagnosed as knee osteoarthritis

• aged between 50-65 years

• volunteer to participate in the study

Exclusion Criteria:

• limitation of cooperation

• moderate to severe dementia or mental retardation, which may cause limitations in examination, testing and treatment

• refusal to participate in the study

• pprevious total knee prosthesis surgery

• secondary osteoarthritis

Related Conditions & MeSH terms

• Knee Osteoarthritis
• Osteoarthritis
• Osteoarthritis, Knee

Intervention

Diagnostic Test:
• ultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionality
ultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionality

Locations

Country	Name	City	State
Turkey	Kanuni Sultan Suleyman Training and Research Hospital	Istanbul	Kucukcekmece

Sponsors (1)

Lead Sponsor	Collaborator
Kanuni Sultan Suleyman Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	ultrasonography	measurement of femoral cartilage thickness	1 day
Primary	Visual Analog Scale	evaluation of pain severity	1 day
Primary	Western Ontario and McMaster Universities Osteoarthritis Index	evaluation of functionality	1 day
Primary	neutrophil account	neutrophil account	1 day
Primary	lymphocyte account	lymphocyte account	1 day
Primary	monocyte account	monocyte account	1 day
Primary	platelet account	platelet account	1 day
Primary	eritrocyte sedimentation rate	eritrocyte sedimentation rate	1 day
Primary	C-reactive protein	C-reactive protein	1 day