Elasticity of the Hoffa's Fat Pad in Patients With Knee Osteoarthritis

Knee Osteoarthritis Clinical Trial

Official title:

Elasticity of the Hoffa's Fat Pad in Patients With Knee Osteoarthritis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05439317
• Other study ID #: 2021-09-013AC
• Status: Completed
• Start date: December 3, 2021
• Est. completion date: August 5, 2022

Study information

• Verified date: February 2023
• Source: Taipei Veterans General Hospital, Taiwan
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Knee osteoarthritis (OA) is a common problem in clinical settings. Knee OA is well known for its association with the wear and tear of the cartilage and osteophyte formation. Evidence has suggested the importance of the infrapatellar fat pad, known as Hoffa's fat pad, during the development of knee OA. Some studies have demonstrated the protective role of the infrapatellar fat pad, whereas others have suggested an inflammatory role such as increased fibrosis and proinflammatory cytokine levels. Ultrasound is exceptionally convenient in the assessment of the musculoskeletal system, and elastography is a tool to evaluate tissue texture. Therefore, in this study, we investigated the Hoffa's fat pad in knee OA patients by using elastography.

Description:

This was an observation study that included a control group. We enrolled 20 patients with knee OA, as well as 10 healthy individuals. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Kellgren-Lawrence X-ray grading were employed to determine disease severity. All the study participants received elastography assessment, including strain and shear wave elastography in the knee extension and flexion position. The strain elastography contained color mapping that enabled the calculation of the relative texture and strain ratio. The shear wave elastography revealed the qualitative velocity, which was measured 3 times. Each patients with knee OA received elastography examination twice: once before hyaluronic acid injection and once 1 month after the injection.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 33
• Est. completion date: August 5, 2022
• Est. primary completion date: April 11, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 86 Years

Eligibility

Inclusion Criteria:

OA group

• Kellgren-Lawrence grading I-IV proved by knee X-ray Healthy group

• No knee pain or received injection during the past 1 year

• No history of knee OA

Exclusion Criteria:

• History of knee surgery, trauma or malignancy

• History of patellar tendinopathy or patellofemoral pain syndrome

• Refused informed consent

Related Conditions & MeSH terms

• Elasticity Imaging Techniques
• Knee Osteoarthritis
• Osteoarthritis
• Osteoarthritis, Knee

Locations

Country	Name	City	State
Taiwan	Taipei Veterans General Hospital	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
Taipei Veterans General Hospital, Taiwan

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	shear modulus	the absolute quantitative measurement of elasticity (kPa) of Hoffa's fat pad	before and 1-3 months after hyaluronic acid injection
Primary	strain ratio	the semiquantitative measurement of elasticity of Hoffa's fat pad, a ratio with patellar tendon as reference	before and 1-3 months after hyaluronic acid injection
Primary	thickness of Hoffa's fat pad	the thickness of Hoffa's fat pad from mid patellar tendon to femur cartilage	before and 1-3 months after hyaluronic acid injection