The Relationship Between Disease Severity and Various Lower Extremity Parameters in Individuals With Knee Osteoarthritis

Knee Osteoarthritis Clinical Trial

Official title:

The Relationship Between Disease Severity and Various Lower Extremity Parameters in Individuals With Knee Osteoarthritis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05294224
• Other study ID #: 210077/10
• Status: Completed
• Start date: April 17, 2022
• Est. completion date: September 30, 2023

Study information

• Verified date: March 2024
• Source: Mugla Sitki Koçman University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study perform to investigate the relationship between quadriceps femoris (QF) strength, QF thickness, femoral cartilage thickness, knee function, balance, kinesiophobia and gait of the patients with knee osteoarthritis.

Description:

Osteoarthritis (OA) is one of the most common chronic degenerative diseases in the world, which progresses slowly, can cause pain, stiffness and dysfunction, and reduces the quality of life.

OA is particularly common in weight-bearing joints such as the knee and the functional status of patients with OA is adversely affected various factors such as immobility due to pain, decrease in muscle strength and joint range of motion, etc.

In relation to this, walking difficulty and decrease in walking speed, balance problems and an increase in the risk of falling are a picture that can be encountered in the later stages of the disease.

The aim of this study is to investigate the relationship between QF strength, QF thickness, femoral cartilage thickness, knee function, balance, kinesiophobia and gait of the patients with knee OA.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: September 30, 2023
• Est. primary completion date: August 30, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Volunteer patients who applied to the Physical therapy and Rehabilitation department with knee pain

Exclusion Criteria:

• Individuals who have received intra-articular therapy for gonarthrosis in the last 6 months, who have undergone arthroscopic surgery, and who have additional pathologies in their lower extremities

• Individuals with physical, mental and/or psychological disorders that may affect participation in the study

Related Conditions & MeSH terms

• Knee Injuries
• Knee Osteoarthritis
• Osteoarthritis
• Osteoarthritis, Knee

Locations

Country	Name	City	State
Turkey	Mugla Sitki Koçman University	Mugla

Sponsors (2)

Lead Sponsor	Collaborator
Dilara Özen Oruk	Mugla Sitki Koçman University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	QF muscle thickness	QF muscle thickness	Day 1
Primary	QF muscle strength	QF muscle strength	Day 1
Primary	Femoral cartilage thickness	Femoral cartilage thickness	Day 1
Primary	Knee function	Knee function assessment with The Knee injury and Osteoarthritis Outcome Score (KOOS). It is a 42-item questionnaire, including 5 subscales: symptoms, pain, ADLs, sports/recreation, and quality of life. The maximum score a patient can achieve is 100, indicating no knee problems. The minimum score is zero, indicating severe knee problems.	Day 1
Primary	Kellgreen-Lawrence Radiological Stages	Kellgreen-Lawrence Radiological Stages: Grade 1 (doubtful): doubtful joint space narrowing and possible osteophytic lipping. grade 2 (minimal): definite osteophytes and possible joint space narrowing. grade 3 (moderate): moderate multiple osteophytes, definite narrowing of joint space and some sclerosis and possible deformity of bone ends.	Day 1
Primary	Kinesiophobia	Tampa Kinesiophobia Scale: The total score of the scale range from 17- 68, where 17 means no kinesiophobia, 68 means severe kinesiophobia, and score ± 37 indicates there is kinesiophobia.	Day 1
Primary	Balance and gait	Tinetti Score: It uses a 3-point ordinal scale of 0, 1 and 2. Gait is scored over 12 and balance is scored over 16 totalling 28. The lower the score on the Tinetti test, the higher the risk of falling.	Day 1
Primary	Low Extremity Functionality and Fall Risk	30 sec sit to stand test	Day 1