Comparing Effect of Autologous Platelet-Rich Plasma Versus Hyaluronic Acid

Status Completed

Clinical Trial Summary

To compare the efficacy and structural change of intraarticular single platelet-rich plasma(PRP) versus novel crosslinked Hyaluronic Acid(HA)(HyajointPlus) for the treatment of early stage knee osteoarthritis(OA). This was a prospective, double-blind, RCT with an allocation ratio of 1:1.

Clinical Trial Description

In the PRP group, an Aeon Acti-PRP set was used and an approximately 4-mL PRP volume was yielded and was used in a single-dose treatment. In the HA group, HYAJOINT Plus containing 60 mg of purified sodium hyaluronate was used in a single-dose treatment. All PRP and HA injection syringes were covered with opaque envelop, and the intra-articular injection procedure was performed by the same physician without ultrasound or other imaging guidance. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04972383
Study type	Interventional
Source	Kaohsiung Medical University Chung-Ho Memorial Hospital
Contact
Status	Completed
Phase	Phase 3
Start date	November 7, 2017
Completion date	October 16, 2019

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Comparing Effect of Autologous Platelet-Rich Plasma Versus Hyaluronic Acid Treatment on Knee Osteoarthritis

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms