Knee Osteoarthritis Clinical Trial
Official title:
Cost Effectiveness of Two-stage Algorithm (Prolotherapy Injections Prior to Total Knee Arthroplasty) in the Management of Advanced Stage Knee Osteoarthritis
This study compared the cost effectiveness of two-stage algorithm (prolotherapy injections (PrT) combined with rehabilitation protocol (RP) prior to total knee arthroplasty (TKA)) and one-stage algorithm (TKA) in the management of advanced stage knee osteoarthritis.
The aim of the present study was to compare the cost effectiveness of two-stage algorithm
(prolotherapy injections (PrT) combined with rehabilitation protocol (RP) prior to total knee
arthroplasty (TKA)) and one-stage algorithm (TKA) in the management of advanced stage knee
osteoarthritis.
A total of 197 patients who had chronic knee osteoarthritis were included in the present
study. The patients were divided into two groups as two-stage algorithm (PrT combined with RP
prior to TKA), (Group A, n=98) and one-stage (TKA),(Group B, n=99). Clinical effectiveness
was evaluated via Visual Analog Scale (VAS), The Western Ontario and McMaster Universities
Arthritis Index (WOMAC) at baseline and 3-, 6-, 12-, and 18-month follow-ups. Utility scores
of the groups were obtained by extracting and converting WOMAC scores to health utilities
index mark 3 scores. Cost-utility per quality-adjusted life years (QALY) and Incremental
cost-effectiveness ratios (ICERs) of each group were calculated.
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