Knee Osteoarthritis Clinical Trial
Official title:
A Randomised Controlled Trial Comparing Single Shot Adductor Canal Block With Femoral Nerve Block for Analgesia Post Total Knee Arthroplasty
Total knee arthroplasty or replacement (TKA) is a surgery performed for osteoarthritis of
the knee which is increasingly performed as the population ages. It is a painful surgery and
one of the methods to reduce post-operative pain is performing a regional anaesthesia
technique. The current practice is to perform a femoral nerve block (FNB) which blocks the
nerves supplying the knee joint and the thigh muscles (quadriceps). This provides effective
analgesia. However, it also results in weakness of the quadriceps and may result in falls
post-operatively.
Adductor canal block (ACB) is a new, alternative regional anaesthesia technique which is
hypothesised to provide as effective analgesia, with less quadriceps weakness compared to
FNB, hence potentially reducing the risk of falls post-operatively.
Investigators aim to study if the analgesia provided by ACB is as good as FNB while
preserving quadriceps strength.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | December 2014 |
Est. primary completion date | September 2014 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 45 Years to 85 Years |
Eligibility |
Inclusion Criteria: - ages 45-85 - American Society of Anaesthesiologists physical status 1-3 - BMI 18-35 kg/m2 Exclusion Criteria: - inability to give consent, communicate, cooperate - Patients with regular consumption of strong opioids (morphine, oxycodone) or steroids - Patients with allergy to local anaesthetics or any drugs included in the study - Patients with lower limb surgery in the preceding year - Patients with pre-existing neurological deficits - Patients who are unsuitable for general anaesthetics (eg difficult airway) |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Singapore | Changi General Hospital | Singapore |
Lead Sponsor | Collaborator |
---|---|
Changi General Hospital |
Singapore,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Morphine consumption | first 24 hours | No | |
Secondary | Pain scores | 1, 6, 12, 24, 48 | No | |
Secondary | Morphine consumption | 48 hours | No | |
Secondary | Side effects of opioids- sedation, nausea and vomiting | 48 hours | Yes | |
Secondary | Quadriceps strength, ability to mobilise | 24, 48 hours | No |
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