Knee Osteoarthritis Clinical Trial
Official title:
Painful Knee Prosthesis. Relationship Between Endogenous Analgesia and Persistent Post Surgical Pain.
This is a prospective, observational study, aimed to establish the relationship between an inefficient endogenous pain modulation before surgery (total knee arthroplasty; TKA) and the probability to develop chronic pain after surgery (persistent post surgical pain). Endogenous analgesia efficiency will be measured during the month previous to surgery using quantitative sensory testing (QST). Persistent post surgical pain will be defined as presence of pain in movement greater than 3 points in a 0-10 numerical scale in the operated knee, 6 months after surgery.
Status | Recruiting |
Enrollment | 177 |
Est. completion date | December 2016 |
Est. primary completion date | October 2015 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Older than 18 patients - Scheduled for primary total knee arthroplasty - Disposition to visits and scheduled tests Exclusion Criteria: - Previous surgery on knee to be operated - Documented peripheral neuropathy - Severe disease or condition that could potentially interfere with interpretation of tests. |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Spain | Servicio d'Anestesia i Reanimació, Hospital del Mar | Barcelona |
Lead Sponsor | Collaborator |
---|---|
Parc de Salut Mar |
Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Presence of pain in the operated knee, 6 months after surgery. | Presence of pain greater than 3 points in a 0-10 numerical scale in the operated knee, 6 months after surgery. | Yes | |
Secondary | Endogenous Analgesia efficiency measured with QST (Quantitative sensory testing) techniques. | From start of recruitment untill day 180. | No |
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