Knee Osteoarthritis Clinical Trial
Official title:
Assessment of Efficacy of Low Intensity Resistance Training in Women at Risk for Symptomatic Knee Osteoarthritis
The purpose of this study is to asses the efficacy of a 4 week low-intensity resistance
training program with concurrent application of partial blood flow restriction (PBFR) to the
exercising limbs to improve quadriceps strength and size, leg muscle power, and mobility in
women at risk for developing symptomatic knee osteoarthritis. The primary outcome will be
change in isotonic double leg-press 1 repetition maximum (1RM) strength. The investigators
will test the following hypotheses. In comparison with low-intensity resistance training
without use of PBFR, a four-week low-intensity resistance-training program with PBFR will:
Primary Hypothesis: Increase (a) double leg-press 1RM strength and (b) isokinetic knee
extensor strength
Secondary Hypotheses:
1. Increase quadriceps muscle volume assessed by MRI
2. Increase lower limb muscle power on (a) double leg-press at 40% 1RM and (b) a timed
stair climb
3. Not adversely effect knee pain or quality of life assessed by the Knee injury and
Osteoarthritis Outcome Score (KOOS) questionnaire
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
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