Effects of Joint Effusion on Quadriceps Muscle

Knee Osteoarthritis Clinical Trial

Official title:

Effects of Joint Effusion on Quadriceps Muscle in Patients With Knee Osteoarthritis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01314820
• Other study ID #: KC09OISI0161
• Status: Completed
• Phase: N/A
• First received: March 14, 2011
• Last updated: March 14, 2011
• Start date: June 2009
• Est. completion date: June 2010

Study information

• Verified date: January 2010
• Source: The Catholic University of Korea
• Contact: n/a
• Is FDA regulated: No
• Health authority: Korea: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

The present study investigated whether the presence of fluid in the joint affected peak torque and the root mean square (RMS) values of surface electromyography (EMG) in patients symptomatic for osteoarthritis (OA).

Description:

Several studies have shown that knee effusion influenced quadriceps muscle activity and induced quadriceps arthrogenic muscle inhibition in normal volunteers. However, the effect of joint effusion on the quadriceps of patients with OA is controversial,and few patients with OA have been included in studies of joint effusion.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: June 2010
• Est. primary completion date: January 2010
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 50 Years to 75 Years

Eligibility

Inclusion Criteria:

• 50 years old or older with knee osteoarthritis

• knee pain without joint effusion confirmed by ultrasonography

Exclusion Criteria:

• the presence of knee joint effusion determined using US

• a history of knee injury or surgery

• a history of knee injection within 3 months

• a history of inflammatory arthritis

• taking anticoagulants

• balance or gait disturbance

• diabetes mellitus

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Knee Osteoarthritis
• Osteoarthritis
• Osteoarthritis, Knee

Intervention

Other:
• normal saline injection
20 cc normal saline injection into knee joint
• sham injection
no saline injection

Locations

Country	Name	City	State
Korea, Republic of	Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
The Catholic University of Korea

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (3)

Fahrer H, Rentsch HU, Gerber NJ, Beyeler C, Hess CW, Grünig B. Knee effusion and reflex inhibition of the quadriceps. A bar to effective retraining. J Bone Joint Surg Br. 1988 Aug;70(4):635-8. — View Citation

Jones DW, Jones DA, Newham DJ. Chronic knee effusion and aspiration: the effect on quadriceps inhibition. Br J Rheumatol. 1987 Oct;26(5):370-4. — View Citation

Rice D, McNair PJ, Dalbeth N. Effects of cryotherapy on arthrogenic muscle inhibition using an experimental model of knee swelling. Arthritis Rheum. 2009 Jan 15;61(1):78-83. doi: 10.1002/art.24168. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the peak torque of the knee extensors	to evaluate the effect of effusion on the peak torque of the knee extensors	within 5 minutes after intervention	No
Secondary	the root mean square values of the vastus medialis and vastus lateralis muscles	to evaluate the effect of effusion on the RMS of the vastus medialis (VM) and vastus lateralis (VL) muscles	within 5 minutes after intervention	No