Efficacy of Intra-articular Injection of Human Amniotic Suspension Allograft and Platelet-rich Plasma in the Treatment of Knee Osteoarthritis.

Knee Osteoarthristis Clinical Trial

Official title: Comparison of the Efficacy of Intra-articular Injection of Human Amniotic Suspension Allograft and Platelet-rich Plasma in the Treatment of Knee Osteoarthritis: A Prospective, Double-blind, Randomized Controlled Trial

Status Not yet recruiting

Clinical Trial Summary

A double-blind, randomized controlled trial designed to evaluate the symptomatic modulating efficacy of amniotic suspension allograft (ASA) in comparison to platelet-rich plasma (PRP), hyaluronic acid (HA) and normal saline (NS) in the injection treatment of knee osteoarthritis. The hypothesis is that ASA would provide the greatest functional improvement.

Clinical Trial Description

At least 150 subjects with osteoarthritic knee will be recruited and computer randomized 1:1:1:1 to single injection of ASA (40mg), ASA (20mg), PRP + HA, and NS groups. Both subjects and evaluaters were blinded to allocations. Functional and radiologic outcomes were measured at baseline, and 1 week, 1, 3, 6, 12 months postinjection. ;

Related Conditions & MeSH terms

• Knee Osteoarthristis
• Osteoarthritis
• Osteoarthritis, Knee

• NCT number: NCT04698265
• Study type: Interventional
• Source: Kaohsiung Veterans General Hospital.
• Contact: Kuan-Yu Lin
• Phone: +886-7-3422121
• Email: johnkyl@yahoo.com
• Status: Not yet recruiting
• Phase: N/A
• Start date: January 1, 2021
• Completion date: January 31, 2023