Probucol for Symptomatic Intracranial & Extracranial Artery Stenosis

Status Not yet recruiting

Clinical Trial Summary

Clinical Trial Description

This study is a multicenter, double-blind, placebo-controlled, randomized clinical trial that aims to evaluate the efficacy of probucol on the reduction of the risk of recurrent stroke in patients with symptomatic intracranial or extracranial arterial stenosis. During the study period, 5452 patients at intermediate risk for ischemic stroke or TIA will be enrolled from 100 centers.To evaluate whether probucol, as compared with placebo, reduces the risk of recurrent stroke in patients at high risk for ischemic stroke or TIA within 7 days of onset.Patients in one arm will receive probucol initiated with a dose of 1000 mg per day on days 1 through 30, and continuing with 500 mg per day after day 31, and those in the other arm will receive an equivalent placebo drug. Study visits will be performed on the day of randomization, at discharge, at day 90 and at 1 year and then followed up annually until the occurrence of the endpoint event or the end of the study. In addition, patients will be followed up at any time when new clinical symptoms of the neurologic system and suspicious events occur, including worsening of the original ischemic event and the appearance of new transient or persistent neurologic symptoms. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06225752
Study type	Interventional
Source	First Affiliated Hospital of Wannan Medical College
Contact
Status	Not yet recruiting
Phase	Phase 3
Start date	April 1, 2024
Completion date	October 31, 2026

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Probucol for Symptomatic Intracranial and Extracranial Artery Stenosis

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms