Ischemic Stroke Clinical Trial
— RADICALOfficial title:
Thrombo-inflammation Biomarkers Trial in Acute Cerebral Hypoxia. A Case-control Trial Nested in a Cohort
NCT number | NCT04971564 |
Other study ID # | FDE_2021_19 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | March 19, 2024 |
Est. completion date | June 22, 2026 |
The goal of this trial is to study, in three well-defined clinical situations responsible for cerebral hypoxia, the concentrations of biomarkers of thrombo-inflammation compared to a population of patients without cerebral hypoxia, and to study in patients with cerebral hypoxia the association between these concentrations and the clinical evolution.
Status | Recruiting |
Enrollment | 200 |
Est. completion date | June 22, 2026 |
Est. primary completion date | June 22, 2026 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Admitted to the Rothschild Foundation within the first 24 hours of an acute neurological symptomatology related to : - ischemic stroke eligible for a mechanical thrombectomy procedure - subarachnoid haemorrhage due to aneurysmal rupture: patient with at least a modified Fisher scale 3 or 4 (Appendix 4) and a World Federation of Neurological Surgeons (WFNS) score of 2 or more - intra-parenchymal haematoma with a Glasgow Coma Scale (GCS) strictly below 15. - tissue-based transient ischaemic attack - no lesion found on imaging - with ABCD2= 2 (control group). - Hospitalisation to the Fondation Adolphe de Rothschild Hospital at least 72 hours is planned Exclusion Criteria: - Pre-existing functional and/or cognitive disability - Patient under legal protection - Pregnant or breastfeeding woman |
Country | Name | City | State |
---|---|---|---|
France | Hôpital Fondation Adolphe de Rothschild | Paris | Ile-de-France |
Lead Sponsor | Collaborator |
---|---|
Fondation Ophtalmologique Adolphe de Rothschild |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Biomarker rates at day 0 | Biomarker: Neutro-Plaket aggregates, extra-cellular DNA networks, von Willebrand Factor | 24 hours |
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