Ischemic Stroke Clinical Trial
Official title:
Morphologic Evolution and Remodeling of Intracranial Atherosclerosis: A Longitudinal Study by 3D-rotational Angiography
This study is to elucidate the morphologic evolution and remodeling of ICAD under stringent control of cardiovascular risk factors.
Status | Recruiting |
Enrollment | 140 |
Est. completion date | June 30, 2024 |
Est. primary completion date | December 28, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: 1. Patient is 30 to 85 years of age, inclusive. 2. Patients who have an acute infarct in diffusion-weighted MRI compatible with artery-to-artery thrombo-embolism and a relevant intracranial atherosclerotic stenosis =60%. 3. Patient who has no contra-indication for the proposed imaging tests. 4. Patient understands the purpose and requirements of the study, and has provided an informed consent. Exclusion Criteria: Patient with any of the following conditions would be excluded: 1. Stroke etiology uncertain or unrelated to intracranial atherosclerosis, such as cardioembolism, Moyamoya disease, small vessel disease or primary angiitis of CNS. 2. A tandem stenosis >50% at extra-cranial internal carotid artery. 3. Bleeding propensity: active peptic ulcer disease, major systemic hemorrhage within 30 days, thrombocytopenia (platelets <100 x 109/L), coagulopathy (INR >1.5). 4. A medical condition that would not allow the patient to adhere to the protocol or complete the study. |
Country | Name | City | State |
---|---|---|---|
Hong Kong | Chinese University of Hong Kong | Hong Kong |
Lead Sponsor | Collaborator |
---|---|
Chinese University of Hong Kong |
Hong Kong,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Morphologic Evolution and Remodeling of Intracranial Atherosclerosis | The 3DRA images (the disparity in morphological attributes, including surface outline, angulations, plaque volume and distribution) of the patients in pre and post 12 month follow-up would be compared. | Dec, 2019 |
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