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Morphologic Evolution and Remodeling of Intracranial Atherosclerosis: A Longitudinal Study by 3D-rotational Angiography

Ischemic Stroke Clinical Trial

Official title:
Morphologic Evolution and Remodeling of Intracranial Atherosclerosis: A Longitudinal Study by 3D-rotational Angiography

Clinical Trial Summary

This study is to elucidate the morphologic evolution and remodeling of ICAD under stringent control of cardiovascular risk factors.

Clinical Trial Description

The investigator has conducted extensive research on ICAD by transcranial Doppler ultrasound, CT angiography and perfusion studies, magnetic resonance imaging (MRI) and digital subtraction angiography (DSA) respectively. Currently, the investigator applied 3-dimensional rotational angiogram (3DRA), a selective intra-arterial catheter-based imaging technique that had a superior spatial resolution compared with CT, MRI or DSA in depicting minute (<3mm) angio-architecture. Through 3DRA, the investigator could appreciate the ICAD patho-anatomy from a near-infinite number of planes, analyzing the stroke mechanisms and morphological changes with much improved precision. A neuro-radiologist and a stroke neurologist blind to time sequence will measure the geometric parameters and the luminal narrowing by WASID method. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03295773
Study type Observational
Source Chinese University of Hong Kong
Contact Thomas Wai Hong LEUNG, FRCP
Phone 852-35053593
Email drtleung@cuhk.edu.hk
Status Recruiting
Phase
Start date August 22, 2016
Completion date June 30, 2024
View Details
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