Multiple Burrhole Therapy With Erythropoietin for Unstable Moyamoya

Status Completed

Clinical Trial Summary

In this study, the investigators aim to evaluate the indirect revascularization outcomes of a new combination therapy of multiple burrhole procedure with promotion of arteriogenesis by intravenous (IV) erythropoietin (EPO) pretreatment on Moyamoya patients with acute neurological presentation, and outline the clinical and vascular factors associated with revascularization through the burrholes.

Clinical Trial Description

This is a investigator led, single-center, single arm, interventional trial in prospective Moyamoya disease (MMD) and Moyamoya syndrome (MMS) registry. MMD or MMS patients with acute neurological presentation such as ischemic stroke or transient ischemic attack are eligible.

After inclusion, initial evaluation including transfemoral angiography is performed. A 3 day pre-procedure IV erythropoietin (120000 international units[IU] #3) is given for promotion of arteriogenesis, than multiple burrhole procedure is performed. Arteriogenesis is evaluated by 6 month transfemoral angiography. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03162588
Study type	Interventional
Source	Ajou University School of Medicine
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	May 1, 2010
Completion date	September 30, 2016

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