Ischemic Stroke Clinical Trial
Official title:
Granulocyte-Colony Stimulating Factor In Ischemic Stroke (GIST): A Pilot Study
1. Circulating bone marrow and blood vessel precursors home in to sites of ischemia and
aid regeneration of injured tissue
2. Increasing the number of circulating precursors will improve in regeneration of damaged
brain following ischemic stroke.
We hypothesize that mobilization of bone marrow precursor cells into the blood stream will
allow them to redistribute in the injured central nervous system and aid regeneration of
damaged tissue. If the hypotheses is correct, it predicts that G-CSF treatment will improve
the functional outcome of patients following acute ischemic stroke.
Underlying this work are the following considerations:
- Currently the clinical and functional outcomes following ischemic strokes are poor and
require new treatment strategies.
- G-CSF administration is a well established routine treatment for the mobilization of
hematopoietic and endothelial precursors from the bone marrow into the circulation.
- Acute ischemia locally increases factors that direct circulating bone marrow derived
cells to home to these sites of injury.
- Evidence exists that bone marrow derived cells are able to repopulate different tissues
including those of the CNS.
- Acute ischemic injury to the central nervous system provides a milieu for the
regeneration of neural tissue.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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