Ischemia Reperfusion Injury Clinical Trial
Official title:
Effect of Orally Pregabalin Given Before Knee Joint Replacement on Reperfusion Injury Which Caused by Bandage
The application of tourniquet is indispensable for a bloodless surgical area in total knee arthroplasty surgery. The release of tourniquet produces reactive oxygen species which can cause injury and then ischemia-reperfusion injury emerge. Our aim in this study is to investigate effects of pregabalin, GABA analog drug, on the tourniquet induced ischemia-reperfusion injury.
Investigators will randomize patients into two groups. 1) Pregabalin group 2) Control group.
Investigators will give orally pregabalin 150 mg to the pregabalin group patients two times
(first dose 1 day before surgery., second dose 1 hour before surgery). On the other hand
placebo drug will give to the control group at the same times. Investigators will perform
combined spinal epidural anesthesia for surgery and inject 3 cc 0.5% hyperbaric bupivacaine
to subarachnoid space. Investigators will take blood samples for measurement of
ischemia-reperfusion determinants, immediately before surgery, shortly before tourniquet
deflation, and 20 minutes after tourniquet deflation. Then these samples will be analysed by
ELISA method.
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