Ischemia-Reperfusion Injury Clinical Trial
Official title:
Inhaled Nitric Oxide in Prevention/Treatment of Ischemia-Reperfusion Lung Injury Related to Lung Transplantation
The purpose of this study is to evaluate the effects of inhaled nitric oxide on both short-term physiology as well as on the development of ischemia-reperfusion lung injury (IRLI) in the immediate post transplant period. The specific hypothesis is that inhaled NO post lung transplantation will improve gas exchange/hemodynamic and thus reduce the development of post transplant IRLI.
The objective is to determine the role of inhaled NO in the prevention/treatment of IRLI in
lung transplant patients. The plan is to accomplish this objective in 2 phases:
Phase 1 - patients immediately post transplant will have a variety of physiologic
measurements performed while breathing 0, 10, and 20 ppm inhaled NO. For the next 24 hours
they will be kept on a mixture providing the best oxygen delivery and pulmonary artery
pressure. Our specific aims in this phase are to characterize physiologic responses to
inhaled NO and determine the incidence of IRLI in these patients over 24 hours.
Phase 2 - patients immediately post transplant will be randomized to either INO or placebo
gas and followed for 24 hours. Our specific aim in this phase is to compare the rate of
development of IRLI in the two groups.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05327348 -
Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery
|
Phase 3 | |
| Completed |
NCT00184912 -
The Effect of Caffeine on Ischemic Preconditioning
|
N/A | |
| Recruiting |
NCT05585255 -
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury
|
||
| Completed |
NCT05598177 -
Effect of Dexmedetomidine Preconditioning on Myocardial Ischemia-reperfusion Injury in Patients Undergoing Open Heart Surgery With Cardiopulmonary Bypass
|
Phase 4 | |
| Completed |
NCT04284592 -
Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery
|
N/A | |
| Withdrawn |
NCT00441714 -
Effect of Ischemic Postconditioning on Targeting of Annexin A5 After Forearm Exercise
|
N/A | |
| Completed |
NCT00248040 -
Reparixin in Prevention of Delayed Graft Function After Kidney Transplantation
|
Phase 2 | |
| Completed |
NCT01486212 -
Ischemia-reperfusion Injury Model on Healthy Volunteers and Measurement of Oxidative and Inflammatory Markers
|
N/A | |
| Recruiting |
NCT06097702 -
A Study to Evaluate the Safety and Pharmacokinetics of BX-001N in Healthy Participants
|
Phase 1 | |
| Completed |
NCT01073202 -
Effects of Ursodeoxycholic Acid on Graft Recovery Early After Adult Liver Transplantation
|
N/A | |
| Completed |
NCT00224406 -
Repertaxin in Prevention of Primary Graft Dysfunction After Lung Transplantation
|
Phase 2 | |
| Active, not recruiting |
NCT05246618 -
FIH Phase I/IIa Trial Evaluating Safety of TUM012 to Minimize Ischemic Reperfusion Injury in Kidney Transplantation
|
Phase 1/Phase 2 | |
| Completed |
NCT02118753 -
The Effect of EPLerenone on Ischemia Reperfusion Injury in Human myoCARDium
|
N/A | |
| Completed |
NCT01739088 -
Pediatric Remote Ischemic Pre-conditioning Prior to Complex Cardiac Surgery
|
N/A | |
| Completed |
NCT01040013 -
Gut Oxygenation and Laparoscopy
|
Phase 2 | |
| Suspended |
NCT00184847 -
Adenosine Receptors Influence Ischemia-Reperfusion Injury
|
N/A | |
| Completed |
NCT01172171 -
The Effect of Melatonin on Ischemia-reperfusion Injury Following Acute Myocardial Infarction
|
Phase 2 | |
| Completed |
NCT00457405 -
Does a Seven Day Treatment With Dipyridamole Induce Protection Against Ischemia-Reperfusion Injury?
|
Phase 4 | |
| Completed |
NCT00184821 -
Ischemic Injury and Ischemic Preconditioning in Diabetes
|
N/A | |
| Not yet recruiting |
NCT00691613 -
Infusion of a Single Dose of Erythropoietin to Prevent Injury in an Ischemia Reperfusion Forearm Model
|
N/A |