Clinical Trials Logo

Clinical Trial Summary

This study aims to investigate the inner mechanism during different dehydration therapies such as mannitol injection and hypertonic saline. The investigators used a self-made near infrared spectroscopy (NIRS) instrument to monitor the physiological changes noninvasively including oxyhemoglobin ([HbO2]), deoxy-hemoglobin ([Hb]), the derived change in blood volume ([tHb]) and water concentration on the forehead of brain edema patients.


Clinical Trial Description

Cerebral edema, as an acute head injury along with high intracranial pressure, has been of great interest over decades in clinical neurosurgery research. Dehydration therapy is a common clinical method to decrease intracranial pressure. This study aims to investigate the inner mechanism during different dehydration therapies such as mannitol injection and hypertonic saline. The investigators used a self-made near infrared spectroscopy (NIRS) instrument to monitor the physiological changes noninvasively including oxyhemoglobin ([HbO2]), deoxy-hemoglobin ([Hb]), the derived change in blood volume ([tHb]) and water concentration on the forehead of brain edema patients. Then the investigators compared the changes process of multiple physiological parameters during different dehydration therapies. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03828032
Study type Interventional
Source Chinese Academy of Medical Sciences
Contact
Status Not yet recruiting
Phase N/A
Start date September 1, 2019
Completion date December 11, 2019

See also
  Status Clinical Trial Phase
Completed NCT03653910 - Effect-site Concentration of Remifentanil for Double-lumen Tubes Intubation: Airtraq VS Macintosh Laryngoscope N/A
Completed NCT06000098 - Consol Time and Acute Kidney Injury in Robotic-assisted Prostatectomy
Recruiting NCT02565251 - Volemic Resuscitation in Sepsis and Septic Shock N/A
Terminated NCT02365688 - Hemodynamic Response During Goal Directed Fluid Therapy in the OR N/A
Completed NCT01605279 - Dobutamine Versus Placebo for Low Superior Vena Cava Flow in Newborns Phase 2
Completed NCT01559675 - Trial Comparing Low Dose and High Dose Steroids in Patients Undergoing Colorectal Surgery N/A
Recruiting NCT04010058 - Postoperative Continuous Non-invasive Haemodynamic Monitoring on the Ward N/A
Completed NCT06268275 - Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy N/A
Recruiting NCT04926220 - Dynamic Estimation of Cardiac Output in the Operating Room
Not yet recruiting NCT05003011 - Correlation of Hemodynamics Via Pulmonary Artery Catherization and the Cardiospire
Completed NCT03599440 - Effect of Extended Infusion Lines on Pulse Contour-based Measurements
Completed NCT05035485 - Maternal Cardiac Output Response to Rescue Norepinephrine and Phenylephrine Boluses in Patients With Severe Preeclampsia N/A
Not yet recruiting NCT04227821 - Hemodynamic Optimalization in Pediatric Patients
Completed NCT06158165 - Evaluating The Cardiovascular Effects of Tourniquet Application
Completed NCT05481047 - Prevention or Treatment of Arterial Hypotension and Oxygen Cerebral Saturation During Major Abdominal Surgery N/A
Not yet recruiting NCT04076709 - Cardiovascular Effects of Muscle Relaxation During Laparoscopic Surgery Phase 4
Completed NCT04089098 - VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility
Recruiting NCT05570682 - Manually Controlled Infusion vs Target Controlled Infusion for StrokeThrombectomy N/A
Completed NCT04574908 - A Pilot Trial of Continuous Portable Postoperative Hemodynamic And Saturation Monitoring On Hospital Wards N/A
Recruiting NCT06071026 - Hemodynamic Effects of Variations in Net Ultrafiltration Rate During Continuous Renal Replacement Therapy. N/A