Intracranial Aneurysm Clinical Trial
Official title:
Application of Atorvastatin in the Treatment of Patients With Intracranial Unruptured Aneurysms
This study was designed to identify whether there is a measurable reduction in inflammation in walls of intracranial aneurysms with oral atorvastatin.
Unruptured intracranial aneurysms (UIAs) are increasingly detected and often remain
clinically asymptomatic for a long time before rupture. However, once the UIAs ruptured, the
incidence of mortality rate varies from 30% to 60% within 6 months. Thus, the risk of UIAs
rupture should be weighed, and need an individual criterion for predicting rupture in
clinical decision making.
Histopathological studies indicated that inflammation may play an important role in the
formation, growth, and rupture of UIAs. Wall enhancement of a saccular aneurysm on high
resolution magnetic resonance (HRMRI) is a proven sign of inflammatory change and might
predict an unsteady state of an intracranial saccular aneurysm.
Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase and are established
first-line treatments for hypercholesterolemia. Statins produce a range of pleiotropic
effects in addition to inhibition of cholesterol synthesis, especially to reduce
inflammation, which may be important in reducing the growth and rupture of UIAs.
In the study, participants known to have UIA that is not planned for treatment and has not
yet ruptured, take atorvastatin daily for six months, and have an HRMRI scan before and after
to look for the role of atorvastatin in inflammation.
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