Kidney Transplantation Clinical Trial
Official title:
Intraabdominal Hypertension After Kidney Transplantation : Incidence and Associated Factors
Intraabdominal hypertension (IAH) is a frequent and severe condition affecting intensive care
patients. Gold standard for estimation of intraabdominal pressure is intravesical pressure
(IVP) measurement. IVP measurement is recommended in patients presenting IAH risk factor(s).
Acute kidney injury is the most frequent and described complication of IAH condition.
Patients undergoing kidney transplantation have several risk factors to develop IAH.
Nevertheless, to our knowledge, IAH incidence, associated factors and impact on renal
function recovery remains unknown.
We aim to study IAH incidence, associated factors and impact on renal function recovery in
post kidney transplantation period.
Intraabdominal hypertension (IAH) is a frequent and severe condition affecting 30 to 54% of
intensive care patients. Gold standard for estimation of intraabdominal pressure is
intravesical pressure (IVP) measurement. IAH is defined by IVP elevation above 12mmHg. IVP
measurement is recommended in patients presenting IAH risk factor(s). Acute kidney injury
(AKI)is the most frequent and described complication of IAH condition. IAH related AKI
traduces renal hypoperfusion and its severity seems to correlate with IVP levels.
Patients undergoing kidney transplantation have several risk factors to develop IAH :
abdominal wall surgery, acidosis and hypervolemic resuscitation. Nevertheless, to our
knowledge, IAH incidence, associated factors and impact on renal function recovery remains
unknown.
We aim to study IAH incidence in post kidney transplantation period. Thus, we want to
identify associated factors with IAH development in this context. We also aim to correlate
IVP early evolution with extra-cellular hydration status evolution. Finally, impact of IAH on
renal function recovery will be investigated.
Presupposing that 50 kidney transplantations per year will take place in University Hospital
of Reims (France), we attend to include about 100 patients in this study. With a prevalence
of at least 30% of IAH prevalence (as reported in intensive care units cohorts), enrollment
of 100 patients will permit to estimate IAH prevalence with a 9% precision (with a 95%IC).
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04910867 -
APOL1 Genetic Testing Program for Living Donors
|
N/A | |
| Completed |
NCT02723591 -
To Compare the Effects of Immediate-release Tacrolimus and Astagraf XL on Donor-Specific Antibody (DSA) Formation and the Development of Immune Activation (IA) in de Novo Kidney Transplant Recipients
|
Phase 4 | |
| Completed |
NCT05945511 -
Silent Gallbladder Stone in Kidney Transplantation Recipients: Should it be Treated?
|
||
| Completed |
NCT02234349 -
Bile Acids and Incretins in Pancreas Kidney Transplant Patients
|
N/A | |
| Completed |
NCT04496401 -
PK Study in Diabetic Transplant récipients : From Twice-daily Tacrolimus to Once-daily Extended-release Tacrolimus
|
Phase 4 | |
| Recruiting |
NCT05917795 -
Endoscopic Sleeve Gastroplasty With Endomina® for the Treatment of Obesity in Kidney Transplant Candidates
|
N/A | |
| Not yet recruiting |
NCT05934383 -
Safety and Efficacy of Ultrasound Renal Denervation in Kidney Transplantation Patients With Uncontrolled Hypertension
|
N/A | |
| Withdrawn |
NCT04936971 -
Introduction of mTor Inhibitors and the Activation of the Cytomegalovirus (CMV) -Specific Cellular Immune Response
|
Phase 4 | |
| Not yet recruiting |
NCT04540640 -
Oxygenated Machine Preservation in Kidney Transplantation
|
N/A | |
| Not yet recruiting |
NCT03090828 -
Economic Evaluation of an Education Platform for Patients With End-stage Renal Disease
|
N/A | |
| Recruiting |
NCT02908139 -
Noninvasive Perioperative Monitoring of Arterial Stiffness, Volume and Nutritional Status in Stable Renal Transplant Recipients
|
N/A | |
| Completed |
NCT02560558 -
Bela 8 Week Dosing
|
Phase 4 | |
| Terminated |
NCT02417870 -
Ultra-low Dose Subcutaneous IL-2 in Renal Transplantation
|
Phase 1/Phase 2 | |
| Recruiting |
NCT02154815 -
Pre-emptive Kidney Transplantation Quality of Life
|
N/A | |
| Completed |
NCT02235571 -
iChoose Decision Kidney Aid for End-Stage Renal Disease Patients
|
N/A | |
| Enrolling by invitation |
NCT01905514 -
ImPRoving Adherence to Immunosuppressive Therapy by Mobile Internet Application in Solid Organ Transplant Patients
|
N/A | |
| Completed |
NCT02147210 -
Chronic Transplant Glomerulopathy and Regulation of Expression of Ephrin B1
|
N/A | |
| Recruiting |
NCT01699360 -
The Biomarker for Immunosuppressive Agents Metabolism in Chinese Renal Transplant Recipients
|
Phase 4 | |
| Completed |
NCT01672957 -
ORANGE Study: An Observational Study on Renal Function in Kidney Transplant Patients on Immunosuppressive Therapy Containing CellCept (Mycophenolate Mofetil)
|
N/A | |
| Completed |
NCT01655563 -
Pharmacogenetic Trial of Tacrolimus After Pediatric Transplantation
|
Phase 2 |