Interstitial Lung Disease Associated

Status Completed

Clinical Trial Summary

This single-center, retrospective cohort study was conducted to determine whether ANCA-ILD spectrum share the same clinical manifestations and outcome with CTD feature disease spectrum.

Clinical Trial Description

We retrospectively reviewed patients who had been diagnosed with interstitial pneumonia during outpatient or hospitalization at Peking Union Medical College Hospital (PUMCH) between January 2012 and December 2021. 1. Baseline data collection: 1. Baseline information at the time of initial diagnosis was obtained, and the following items were analyzed: demographic information (age, gender), clinical course, clinical symptoms and signs, laboratory findings [routine blood, erythrocyte sedimentation rate (ESR), hypersensitivity C-reactive protein (Hs-CRP), rheumatoid factor (RF) and serologic autoantibodies], pulmonary function tests (PFTs), and chest HRCT scans. 2. MPO-ANCA and PR3-ANCA titers were measured by ELISA. 3. Chest HRCT images were evaluated by at least two pulmonologists and radiologists. The HRCT scans were analyzed for the following characteristics: ground-glass opacities, reticular patterns, honeycombing, traction bronchiectasis. 4. Spirometry was performed according to standardized guidelines. PFTs results were expressed as percentages of the predicted values, thereby correcting for age, gender and bodyweight. 2. Treatment was defined as the use of corticosteroids ≥ 10mg/d, azathioprine, cyclophosphamide, mycophenolate mofetil, methotrexate, or rituximab. Follow-up was up to the time of patient's last visit or time of death, and the outcomes were defined as death from all causes. 3. Outcome ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06007040
Study type	Observational
Source	Peking Union Medical College Hospital
Contact
Status	Completed
Phase
Start date	January 2012
Completion date	December 2021

View Details

See also
Status	Clinical Trial	Phase
Enrolling by invitation	`NCT04905693` - Extension Study of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis	Phase 3
Recruiting	`NCT05631132` - May Noninvasive Mechanical Ventilation (NIV) and/or Continuous Positive Airway Pressure (CPAP) Increase the Bronchoalveolar Lavage (BAL) Salvage in Patients With Pulmonary Diseases?	N/A
Recruiting	`NCT05417776` - Collagen-targeted PET Imaging for Early Interstitial Lung Disease	Phase 2
Not yet recruiting	`NCT04089826` - Long Term Oxygen Therapy in Patients With Interstitial Lung Disease
Recruiting	`NCT03467880` - Multicenter Study of Impulse Oscillometry in Chinese	N/A
Completed	`NCT00883129` - Comparison of Therapeutic Regimens for Scleroderma Interstitial Lung Disease (The Scleroderma Lung Study II)	Phase 2
Completed	`NCT00362739` - Blood Collection From Individuals With Lung Disease for Genetic Studies	N/A
Recruiting	`NCT06133998` - Effects of Incentive Spirometry With and Without Aerobic Exercises in Interstitial Lung Disease	N/A
Active, not recruiting	`NCT03485378` - Assessment of Precision Irradiation in Early NSCLC and Interstitial Lung Disease	N/A
Recruiting	`NCT04098094` - Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases
Recruiting	`NCT03400839` - Best Clinical Endpoints That Likely Induce Worse Prognosis in Interstitial Lung Diseases
Terminated	`NCT02633293` - An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE	Phase 2/Phase 3
Enrolling by invitation	`NCT05001009` - Goals of Care Conversations Study	N/A
Active, not recruiting	`NCT05068869` - Digital Outpatient Services	N/A
Active, not recruiting	`NCT03727568` - Study Comparing Two Different Methods of Cryobiopsy in the Interstitial Lung Diseases	N/A
Recruiting	`NCT06046547` - Integrating Palliative Care Education in Pulmonary Rehabilitation	N/A
Completed	`NCT04946708` - Virtual Exercise Program in Interstitial Lung Disease (ILD) Patients	N/A
Recruiting	`NCT04139356` - The Effect of Spontaneous Respiration on Pulse-oximetry Measurements	N/A
Recruiting	`NCT03726398` - CompRehensive Phenotypic Characterization of Patients With Scleroderma-Associated ILD and PH	Phase 2/Phase 3
Active, not recruiting	`NCT03295279` - WTC Chest CT Imaging Archive