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Bisphenol A and Muscle Insulin Sensitivity

Insulin Sensitivity Clinical Trial

Official title:
Randomized Trial Examining Oral Consumption of Bisphenol A on Type 2 Diabetes Risk Markers

Clinical Trial Summary

This study examine oral bisphenol A consumption on muscle insulin sensitivity and hepatic glucose suppression. Half of the participants will receive a diet plus BPA and the other half will receive a diet plus no bisphenol A.

Clinical Trial Description

Evidence linking bisphenol A exposure with diabetes risk remains mainly associative in nature, and mechanism linking bisphenol A to type 2 diabetes remains unclear. The investigator's preliminary data suggests that in young adults, single oral BPA consumption significantly decreased glucose, insulin, and C-Peptide responses to an oral glucose tolerance test, suggesting that immediate consumption of bisphenol A has an effect on muscle insulin sensitivity, hepatic glucose suppression and/or digestion and absorption to lower blood glucose, insulin, and C-Peptide concentrations. The present experimental study evaluating the effects of bisphenol A over several days on the pathogenesis of type 2 diabetes will directly assess each of these potential mechanisms using gold standard measures (euglycemic hyperinsulinemic clamp technique and hepatic glucose suppression with glucose stable isotope infusion, and fecal microbiota). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03771066
Study type Interventional
Source California Polytechnic State University-San Luis Obispo
Contact Todd Hagobian, PhD
Phone 805-756-7511
Email thagobia@calpoly.edu
Status Recruiting
Phase N/A
Start date January 1, 2019
Completion date December 31, 2022
View Details
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