Insulin Resistance Clinical Trial
Official title:
Effekte Der Transkutanen Aurikularen Vagus-Nervenstimulation (tVNS) Auf Die Postprandiale Stoffwechselregulation im Menschen
Two important mechanisms play a major role in the pathogenesis of type 2 diabetes: insulin
resistance of the target tissues and the impaired insulin secretion from pancreatic β-cells.
Postprandial factors (such as insulin) are perceived by the human brain and induce signals
that regulate glucose metabolism via the parasympathetic nervous system.
Transcutaneous auricular vagus nerve stimulation (tVNS) can be used on the outer ear to
stimulate the auricular branch of the vagus nerve in humans. Heart rate variability (HRV) in
healthy people can be significantly increased via tVNS, indicating a shift from sympathetic
activity to parasympathetic activity.
The hypothesis is that this postprandial shift results in a change in peripheral glucose
metabolism. In turn, the increased parasympathetic activity could potentially result in a
change in postprandial insulin sensitivity or secretion.
To test this hypothesis, this study investigates the effect of vagal stimulation versus sham
stimulation on insulin sensitivity, on insulin secretion, glucose tolerance, resting energy
expenditure, and on parasympathetic tone (analysis of heart rate variability).
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