The Effects of Renal Denervation on Insulin Sensitivity

Status Completed

Clinical Trial Summary

Renal sympathetic nerves contribute to development of hypertension. Sympathetic overactivity also induces insulin resistance and it could therefore be assumed that a renal denervation might improve insulin sensitivity. Studies have shown that glucose metabolism is improved in patients with treatment resistant essential hypertension both 1 and 3 months after renal denervation compared to a control group with treatment resistant essential hypertension. Fasting glucose, insulin and C-peptide decreased significantly as did insulin resistance assessed by HOMA-IR. The investigators wish to investigate the effect of renal denervation on insulin sensitivity using the gold standard - the hyperinsulinemic euglycemic clamp and to investigate the degree of insulin resistance in muscle, liver and adipose tissue.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Hypertension
Insulin Resistance
Treatment Resistant Essential Hypertension

Clinical Trial Details

NCT number	NCT01631370
Study type	Interventional
Source	University of Aarhus
Contact
Status	Completed
Phase	N/A
Start date	June 2012
Completion date	March 3, 2016

View Details

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