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Clinical Trial Summary

The aim of the study is the effect of lifestyle modification and metformin on hypothyroidism with insulin resistance


Clinical Trial Description

Hypothyroidism happens when the thyroid does not create and release enough thyroid hormone in the body this make the metabolism slow down . Thyroid hormones T3 and T4 maintain a fine balance of glucose homeostasis by acting as insulin agonistic and antagonistic. Hypothyroidism can break this equilibrium and alter glucose metabolism, which can lead to insulin resistance. Insulin resistance is defined clinically as the inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilization in an individual as much as it does in a normal population. In this work we assess the lifestyle modification (i.e. diet and exercise)and metformin on insulin resistance ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06096454
Study type Interventional
Source Assiut University
Contact hossam mohamed youssef, MBBCh
Phone 01014647504
Email dr.hossam.youssef96@gmail.com
Status Not yet recruiting
Phase Phase 4
Start date November 20, 2023
Completion date October 30, 2024

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