Effect of IV Nalbuphine on Nausea & Vomiting Following Intrathecal

Status Not yet recruiting

Clinical Trial Summary

the study aimed to investigate the effect of Iv nalbuphine on postoperative nausea and vomiting and pain with intrathecal morphine on inguinal hernia repair surgery.

Clinical Trial Description

Bupivacaine hydrochloride is a commonly used local anesthetic in spinal anesthesia, however, the duration of spinal analgesia by bupivacaine is limited to about 75- 150 minutes.2 Therefore, various additives have been used with bupivacaine to prolong its effects and improve the quality of analgesia.(1) Opioids are the most popular used adjuvants added to bupivacaine in spinal blockade to obtain a sufficient intraoperative visceral analgesia and increase the duration and quality of postoperative analgesia, with less sympathetic block and hemodynamic effect .(2) morphine is commonly used for analgesia, but is frequently associated with postoperative nausea and vomiting (PONV) and pruritus, These side effects may lead to patient discomfort and prolonged hospital stay thus limiting the usefulness of IT morphine. Nalbuphine is a mu receptor antagonist and a ĸappa receptor agonist.10 When added as an adjunct to intrathecal local anesthetics, it provides good analgesia with decreased incidence and severity of mu receptor side effects(3) Morphine binds most readily to the mu-opioid receptor and less well to the kappa-opioid receptor. So, the undesirable adverse events of morphine are thought to result from agonism at the mu-opioid receptor.5 Many drugs have been tried with morphine to potentiate its analgesic effects or to reduce the adverse events.6 Nalbuphine is a mixed opioid agonist-antagonist that acts mainly through kappa-opioid receptors, and it may attenuate mu-opioid receptor related side effects.3 Moreover, recent studies suggested that the analgesic effects of morphine and nalbuphine may be additive. The addition of nalbuphine to intrathecal bupivacaine plus morphine significantly reduced the incidence and severity of postoperative nausea and vomiting and pruritus without affecting analgesic potency..(4) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05704673
Study type	Interventional
Source	Assiut University
Contact	Rehab Marzouk, master
Phone	01022290058
Email	e01022290058@gmail.com
Status	Not yet recruiting
Phase	N/A
Start date	June 1, 2023
Completion date	June 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03023462` - Efficacy of an Anterior Quadratus Lumborum Block vs. a TAP-block for Inguinal Hernia Repair	N/A
Completed	`NCT04272320` - The Efficacy of Transversalis Fascia Plane Block in Pediatric Inguinal Hernia Repair	N/A
Recruiting	`NCT03904888` - Conventional Versus Robot Assisted Laparoscopic Inguinal Hernia Repair	N/A
Recruiting	`NCT03856710` - Self Fixating Versus Stapled Mesh for Laparoscopic Inguinal Hernia Repair	N/A
Completed	`NCT02240550` - A Comparative Clinical Study to Evaluate the Effectiveness of ProFlor vs. Lichtenstein for Inguinal Hernia Repair	N/A
Completed	`NCT01679353` - Comparison of Analgesic Effect of Magnesium Added to Ropivacaine and Ropivacaine Alone in Caudal Analgesia on Postoperative Pain Control in Pediatric Patients Undergoing Inguinal Hernia Repair	N/A
Completed	`NCT01943760` - Tamadol Wound Infiltration in Children Under Inguinal Hernioplasty	Phase 4
Recruiting	`NCT01450345` - Efficacy of Pre-operative Oral Pregabalin in Ambulatory Inguinal Hernia Repair for Post Operative Pain	Phase 3
Active, not recruiting	`NCT00968773` - Rebound Hernia Repair Device Mesh Trial	Phase 4
Completed	`NCT01000116` - Fibrin Glue Versus Tacked Fixation in Groin Hernia Repair (TAPP)	N/A
Completed	`NCT01117337` - Comparing Non-fixation of Mesh to Mesh Fixation in Laparoscopic Inguinal Hernia Repair	Phase 4
Terminated	`NCT00226161` - Chronic Pain After Inguinal Herniorrhaphy	N/A
Completed	`NCT05837013` - Open and Laparoscopic Total Extraperitoneal Repair Under Spinal Anesthesia Versus General Anesthesia	N/A
Recruiting	`NCT05058378` - Correlation Between Spinal Anesthesia and Perfusion Index
Completed	`NCT01637818` - Long-term Follow-up of Lichtenstein's Operation Versus Mesh Plug Repair	N/A
Recruiting	`NCT05879770` - Is the Use of Prolene as Sufficient as the Use of Wire in Shouldice Surgery to Keep the Recurrence Rate Low After One Year?
Completed	`NCT05159232` - Length of Hospital Stay in Laparoscopic Transabdominal Preperitoneal Vs. Open Mesh Repair in Inguinal Hernia: A Randomised Controlled Trial	N/A
Completed	`NCT05107986` - Laparoscopy in Complicated Groin Hernia
Active, not recruiting	`NCT04328597` - Portuguese Inguinal Hernia Cohort (PINE) Study
Completed	`NCT04033055` - Antalgic Efficacy of CycloMesh™ Soaked in Ropivacaine Hydrochloride in Uncomplicated Inguinal Hernia.	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Effect of IV Nalbuphine on Nausea and Vomiting Following Intrathecal Morphine

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms