Influenza Clinical Trial
The proposed study will evaluate whether the use of non-pharmaceutical methods, such as
surgical masks, isolation of patients and personal hygiene, are acceptable and effective in
preventing the spread of influenza within the family.This will be achieved by conducting a
randomized, controlled, unblinded, clinical trial. Family members of an index case with
influenza like illness, will be randomly allocated to two groups. In the intervention group,
family members will receive comprehensive guidance about sanitation and hygiene, as well as
surgical masks to wear whenever in close contact (3 feet / 1 meter) with the index case. In
addition, they will be asked to isolate the index case as much as possible. In the control
group, family members will receive only standard guidance about sanitation and hygiene
relevant for reducing the transmission of influenza. The primary end-point of the study will
be secondary infection of influenza of at least one of the family members in order to asses
the efficacy of the interventions. In addition, the compliance to those interventions will
be evaluated.
The study hypothesis is that use of non-pharmaceutical methods will be acceptable and will
reduce the secondary infection rate among them by 50%.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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