Evaluation of Zinc Intake on Essential Fatty Acid Metabolism

Status Completed

Clinical Trial Summary

The purpose of this study is to determine the effect of different dietary zinc intakes on fatty acid metabolism and other zinc biomarkers

Clinical Trial Description

This research is a dietary intervention study designed to evaluate the effect of progressive changes in Zn intake on fatty acid metabolism and to correlate those changes with biomarkers of dyslipidemia and insulin resistance. The main objective is to validate plasma fatty acid metabolism as a biomarker of inadequate Zn intake in subjects consuming identical diets with specific Zn content. The relative sensitivity of some fatty acid enzyme activities will also be compared to the DNA strand breaks. In addition to the primary objectives, correlations in enzyme activity with changes in fat metabolism, namely circulating triglyceride and cholesterol, will be determined. This will enable the determination of the effect of a low Zn intake on various aspects of dyslipidemia. Similar correlational analyses will be performed with clinical measures of inflammation and insulin resistance. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03451214
Study type	Interventional
Source	Children's Hospital & Research Center Oakland
Contact
Status	Completed
Phase	N/A
Start date	July 1, 2017
Completion date	June 30, 2018

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