Effect of an Antioxidant-rich Diet During Moderate Altitude Training

Inflammation Clinical Trial

— ALTAX  

Official title:

The Effect of an Increased Intake of Antioxidant-rich Foods on Training Adaptation, Redox-balance and Inflammation Among Elite Athletes During a Moderate Altitude Training Camp

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03088891
• Other study ID #: ALTAX
• Status: Completed
• Phase: N/A
• First received: September 20, 2016
• Last updated: March 19, 2017
• Start date: October 2015
• Est. completion date: November 2015

Study information

• Verified date: March 2017
• Source: University of Oslo
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Athletes, especially in endurance sports, are at increased risk of oxidative stress and inflammation-related diseases and injuries. The production of reactive oxygen and nitrogen species (RONS) and inflammatory markers increase during exercise and especially during altitude training. Antioxidant supplementation is commonly used among athletes in the belief that it prevents oxidative stress and oxidative damage. A transient increase of RONS is however necessary to activate signaling cascades initiating training adaptation. Antioxidant supplementation has been shown to inhibit the exercise effects in several independent studies, possibly by interfering/reducing the signal cascades initiated by RONS. However, it is unknown whether a high intake of antioxidant rich foods can affect the amount of RONS, inflammation markers and/or training adaptation. The investigators want to examine whether an increased intake of natural antioxidants in the form of antioxidant-rich foods fruits, vegetables and berries, in line with the official Norwegian dietary advice can affect antioxidant status, immune function and training adaptation associated with altitude training in Norwegian elite athletes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 35
• Est. completion date: November 2015
• Est. primary completion date: November 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 16 Years to 42 Years

Eligibility

Inclusion Criteria:

• National team athletes, summer endurance sports

Exclusion Criteria:

• Allergies in conflict with the intervention foods

• Use of medication that could affect training and performance

• Injuries that could affect training and performance

Related Conditions & MeSH terms

• Adaptation Reaction
• Inflammation
• Oxidative Stress

Intervention

Other:
• Antioxidant-rich snacks
Bama Smoothies (Bama, Oslo, Norway), Freia Premium Dark Chocolate (Freia, Oslo, Norway), Walnuts (Eldorado, Norway), Dried fruits and berries (Cranberries, Gojiberries, apricots)(Bama, Oslo, Norway and Rema 1000, Norway)
• Control snacks
Milkshake (Tine, Oslo, Norway), YT restitusjonsdrikk (Tine, Oslo, Norway), Bixit (Sætre, Oslo, Norway), Ritz (Mondelez, Oslo, Norway), White chololate (Freia, Oslo, Norway)

Locations

Country	Name	City	State
Norway	Norwegian Olympic Federation	Oslo
Norway	University of Oslo	Oslo

Sponsors (3)

Lead Sponsor	Collaborator
University of Oslo	Norwegian Olympic Federation, Oslo, Norway, Norwegian School of Sport Sciences

Country where clinical trial is conducted

Norway, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Percent change in performance (sport specific tests will be aggregated to one outcome by the use of percent change)	Cycling: 10 000 m on a bike roller; Rowing: 2000 meter on Concept2-apparatus; Paddling: 1000 meter Concept2-apparatus; Swimming: 200 meter	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Primary	Training adaptation	change in Vo2-max	Measured one week before, and one week after the moderate altitude training camp
Primary	Training adaptation for swimmers	For swimming only: 100 meter max speed	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	Change in biomarkers of inflammation	change in cytokine profile e.g. IL-6 ,TNF, CRP measured by multiplex technology	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	change in lean body mass	measured by DXA (iDXA; GE Healthcare)	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	Bone mineral density	measured by DXA (iDXA; GE Healthcare)	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	change in fat mass	measured by DXA (iDXA; GE Healthcare)	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	change in body composition	measured by DXA (iDXA; GE Healthcare)	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	change in body weight	measured by standardized scale	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	Dietary intake (change in food and nutrient intake)	measured by repeated 24 hour recalls	Measured one and three week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	Change in antioxidant status	e.g. FRAP, ORAC, dROM, isoprostanes measured by HPLC	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	biomarkers of antioxidant-rich foods	e.g. carotenoids, flavonoids measured by HPLC	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	Change in whole blood gene expression	Fasting blood samples (PAX-tubes) and samples taken after physical stress test (PAX-tubes). RNA will be isolated and gene expression measured	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	Change in blood lipids		Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	Change hormones		Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	Change in micronutrients	e.g. iron status	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	change response to stress test		Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	Change in hemoglobin	CO-rebreathing-method	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	change in blood volume	CO-rebreathing-method	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	change in plasma volume	CO-rebreathing-method	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	Change in lactate		Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary	Total training load	Training diary	Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp