Inflammation Clinical Trial
— ADhipfractOfficial title:
The Presence of Pre-Alzheimers/Alzheimers Disease (AD) and Neuromarkers Related to Morbidity/Mortality in Patients With Acute Hip Fractures
Verified date | April 2017 |
Source | Sahlgrenska University Hospital, Sweden |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The investigators explore the presence of AD factors beta-amyloid and tau in CSF and plasma to verify AD diagnosis in patients with acute hip fracture. Clinical dementia test is performed prior to operation. Blood samples and CSF samples are collected at surgery and blood samples are collected postoperatively at intervals. Mortality is assessed at 30 days, 3 months and 1 year. Morbidity is assessed at , 3 months and >1 year. Neuromarkers specifically addressing the inflammatory component are to be analyzed and correlated to outcome together with AD markers, as above.
Status | Completed |
Enrollment | 400 |
Est. completion date | December 20, 2016 |
Est. primary completion date | June 22, 2015 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Hip fracture with a planed spinal anesthesia Exclusion Criteria: - Not receiving a spinal anesthesia i.e. no CSF is available |
Country | Name | City | State |
---|---|---|---|
Sweden | Sahlgrenska University Hospital | Molndal | Vastra Gotaland |
Lead Sponsor | Collaborator |
---|---|
Sahlgrenska University Hospital, Sweden |
Sweden,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Mortality and morbidity | interview by phone and death registration | 1year |
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