Inflammation Clinical Trial
Official title:
Effects of Tart Cherry Juice on Oxidative Stress and Inflammation in Older Men and Women
Oxidative stress has been linked to many diseases associated with aging, including coronary
heart disease and Alzheimer's disease. Antioxidants and special proteins in the body work
together to help prevent damage by free radicals. Some studies have indicated that as people
age, they are less able to fight off oxidative stress and have increased levels of
inflammation.
Tart cherries are known to be rich in antioxidants and plant-nutrients. The product we are
using in this study is an all-natural tart cherry juice, mixed with apple juice concentrate
and containing no additives and no preservatives.
We hope to learn whether antioxidant supplementation, such as tart cherry juice, can
measurably decrease oxidative damage and inflammation associated with aging.
Objectives
The primary objective of this pilot study is to investigate whether tart cherry juice
consumption can reduce oxidative stress in older adults as measured by attenuation of
F2-isoprostane responses to a forearm ischemia-reperfusion, and a decrease in urinary
excretion products of oxidative damage. The secondary objective is to examine whether
age-sensitive markers of inflammation are reduced in response to the cherry juice
consumption.
;
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
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