Infertility Clinical Trial
Official title:
Effects of Adding Oestradiol Supplementation in Luteal Phase in Patients Undergoing in Vitro Fertilization/ Intra Cytoplasmic Sperm Injection (IVF/ICSI ) Long Agonist Fresh Embryo Transfer Cycles
Whether oestradiol administration affects the pregnancy rate in long agonist fresh IVF/ICSI cycles. Oestradiol level will be measured the day of HCG trigger to assess whether oestradiol level affects cycle outcome results.
Status | Recruiting |
Enrollment | 2 |
Est. completion date | January 1, 2020 |
Est. primary completion date | December 1, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 20 Years to 38 Years |
Eligibility |
Inclusion criteria: 1. Age group 20-38 years old. 2. Patients Undergoing gonadotropin Releasing Hormone (Gn RH) long agonist protocol, with fresh embryo transfer. 3. Day 3 Grade 1 embryos. 4. Trilamellar endometrium with ranging endometrial thickness from 8 mm to 14 mm. Exclusion criteria: 1. Karyotypic abnormalities in either partner. 2. Patients with uterine abnormalities. 3. G3-G4 quality embryos. 4. Estradiol level 10,000 or more at time of trigger. 5. Cases of egg donation/sperm donation/embryo donation. 6. Polycystic ovary syndrome (PCOS )patients. 7. Poor responders (maternal age >40, Antral follicle counts (AFC )<5, Anti Mullerian Hormone (AMH )<1 and previous trial <5 oocyte retrieved ) (bologna criteria 2011) 8. Those with 3 or more implantation failure. 9. Endometrial thickness <8 or >14mm. 10. Severe male factor. |
Country | Name | City | State |
---|---|---|---|
Egypt | Art Unit/ Obatetrics and Gynecology Department | Cairo | Cair0 |
Lead Sponsor | Collaborator |
---|---|
Cairo University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Implantation rate | Number of gestational sacs per number of embryos transferred per cycle | 4 weeks after embryo transfer of each enrolled patient | |
Secondary | Chemical pregnancy rate | Quantitative Beta Human Chorionic Gonadotropin (BHCG) | Two weeks after embryo transfer of each enrolled patient | |
Secondary | Clinical pregnancy rate | Intrauterine gestational sac with fetal pole with positive pulsation | 4 weeks after embryo transfer of each enrolled patient with positive pregnancy test or 6 weeks from IVF cycle beginning in pregnant patients | |
Secondary | Ongoing pregnancy rate | 12 weeks gestation and more | 10 weeks after embryo transfer of each enrolled patient or 12 weeks from starting IVF cycle in pregnant patients |
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