Infertility Clinical Trial
Official title:
Effects of Adding Oestradiol Supplementation in Luteal Phase in Patients Undergoing in Vitro Fertilization/ Intra Cytoplasmic Sperm Injection (IVF/ICSI ) Long Agonist Fresh Embryo Transfer Cycles
Whether oestradiol administration affects the pregnancy rate in long agonist fresh IVF/ICSI cycles. Oestradiol level will be measured the day of HCG trigger to assess whether oestradiol level affects cycle outcome results.
6. Background and Rationale: Progesterone is essential for successful implantation and
maintenance of early pregnancy . Although the oestrogen is not essential, it is important to
maintain the progesterone level during the pregnancy and promote the transformation of the
endometrium from the secretory to proliferative phase.
Compromised granulosa cells luteinisation could cause infertility or early miscarriage. In
assisted reproductive technologies (ART) cycles, curettage of the granulosa cells during
oocyte retrieval is thought to reduce corpora lutea function and thus progesterone
production, resulting in a decrease in pregnancy rate.
Therefore, luteal support is routinely performed in ART cycles. Consensus has been reached on
the supplementation of progesterone after the day of oocyte retrieval, which was performed in
approximately 80% of the cycles and significantly improved clinical outcomes.However, the
efficacy of oestradiol supplementation in luteal support remains controversial.
Previous studies have shown that the lower the serum estrogen level was at 4, 7 and 9 days
following transplantation, the lower the clinical pregnancy rate. Previous studies showed
that in patients with long or short duration ovulation induction, luteal support with
oestradiol supplementation led to an increased serum estrogen level and an improved pregnancy
rate . It was also found that patients having luteal support with estrogen (4 mg per day) had
a significantly higher clinical pregnancy rate (40.6% vs 21.6%) and a significantly lower
abortion rate (12.8% vs 38%) than those treated with progesterone alone.
In contrast, other investigators have failed to show any benefit of oestradiol
supplementation during the luteal phase and a Cochrane review published in 2015 reported no
differences in rates of live birth or ongoing pregnancy between the progesterone group and
progesterone add oestrogen group. Hence, it remains unclear whether the addition of estrogen
to progesterone for luteal support is associated with higher pregnancy rate and live birth
rate.
In this study, the investigators will evaluate outcomes of patients undergoing IVF/ICSI‐ET
with oestradiol supplementation in addition to progesterone for luteal support. The
investigators also report on the efficacy implications of oestradiol supplementation for
patients undergoing IVF/ICSI‐ET.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03607409 -
Role of Inhibin A as Biomarker for Ovarian Response for IVF Treatment
|
||
Recruiting |
NCT02312076 -
GnRHa for Luteal Phase Support in Long GnRHa Protocol Cycles
|
Phase 4 | |
Terminated |
NCT02161861 -
Improvement of IVF Fertilization Rates, by the Cyclic Tripeptide FEE - Prospective Randomized Study
|
N/A | |
Completed |
NCT03287479 -
Comparison of a Semi-automated Closed Vitrification System (Gavi®) With a Manual Open Vitrification Sytem (Cryotop®)
|
N/A | |
Terminated |
NCT03522350 -
Randomized Trial Comparing EmbryoScope With EmbryoScope+.
|
N/A | |
Completed |
NCT04496284 -
Embryo Transfer Outcomes After Vitrification With Slush Nitrogen Compared to Liquid Nitrogen
|
N/A | |
Completed |
NCT03623659 -
pArtiaL zonA pelluciDa Removal by assisteD hatchINg of Blastocysts
|
N/A | |
Completed |
NCT03895099 -
New Ovarian Stimulation With Random Start, Use of Progestin Protocol for Oocyte Donors
|
Phase 3 | |
Active, not recruiting |
NCT04142112 -
Randomized, Standard-Controlled, Study to Evaluate the Ohana IVF Sperm Preparation Kit, SPeRtility IVF Next Generation
|
N/A | |
Completed |
NCT03152643 -
Cumulative Live Birth Rates After Cleavage-stage Versus Blastocyst-stage Embryo Transfer
|
N/A | |
Recruiting |
NCT03683771 -
Assessment of Endometrial Pattern and Sub-endometrial Vascularity in ICSI Outcome
|
||
Recruiting |
NCT03161119 -
Comparing Two Different Embryo Transfer Catheters
|
N/A | |
Completed |
NCT04108039 -
Micronized Progesterone vs Gonadotropin-releasing Hormone (GnRH) Antagonist in Freeze-all IVF Cycles.
|
N/A | |
Completed |
NCT03678597 -
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Latrunculin B ( ICSI-LB)
|
N/A | |
Completed |
NCT03678610 -
Handling Medium for ICSI With Ionomycin and Latrunculin A
|
N/A | |
Completed |
NCT03678818 -
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Latrunculin A (ICSI-LA)
|
N/A | |
Completed |
NCT03678558 -
Oocyte Vitrification Aided With Cytochalasin B
|
N/A | |
Completed |
NCT03678571 -
Oocyte Vitrification Aided With Latrunculin A
|
N/A | |
Completed |
NCT03678584 -
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Chaetoglobosin A ( ICSI-CA)
|
N/A | |
Completed |
NCT03677492 -
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Cytochalasin D ( ICSI-CD)
|
N/A |