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NCT02323347 Clinical Trial

Cut-Off Progesterone Values Deleterious for In Vitro Fertilization and Fresh Embryo Transfer

Infertility Clinical Trial

Official title:
Cut-Off Progesterone Values Deleterious for In Vitro Fertilization and Fresh Embryo Transfer

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02323347
Other study ID # PROGEDEX2014
Secondary ID
Status Completed
Phase N/A
First received December 11, 2014
Last updated December 22, 2014
Start date January 2009
Est. completion date March 2014

Study information
Verified date December 2014
Source Institut Universitari Dexeus
Contact n/a
Is FDA regulated No
Health authority Spain: Comité Ético de Investigación Clínica
Study type Observational

Clinical Trial Summary

At which deleterious cut off value of progesterone on day of HCG (P-hCG) in our IVF program should fresh embryo transfer (ET) be cancelled?

Description:

There is still an ongoing debate on the effect of subtle increased P-hCG concentration on pregnancy outcome after fresh ET. No consensus on the cut-off value to define increased P-hCG seems to exist. It is accepted that high P advances endometrium, leading to asynchrony between the implanting embryo and the endometrium, and resulting in implantation failure. A freeze all embryos policy and postponement of ET in subsequent frozen-thawed cycle has been proposed.

Recruitment information / eligibility
Status Completed
Enrollment 1901
Est. completion date March 2014
Est. primary completion date March 2014
Accepts healthy volunteers No
Gender Female
Age group 18 Years to 49 Years
Eligibility Inclusion Criteria:

- Fresh embryo transfer

- Progesterone value on day HCG (Human choriogonadotrophin hormone)

Exclusion Criteria:

- Clinical indication for delaying embryo transfer

Study Design

Observational Model: Case-Crossover, Time Perspective: Retrospective

Related Conditions & MeSH terms

Intervention

Other:
• Progesterone
Progesterone level

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Institut Universitari Dexeus

Outcome
Type Measure Description Time frame Safety issue
Primary Clinical Pregnancy 6 weeks after embryo transfer procedure No
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